| 两品系豚鼠屈光状态和眼球径的发展和比较 |
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| 引用本文： | 卫振,张森,蒋丽琴,陈雁虹,吴凯,谢敏,刘迪文,谢强敏. 两品系豚鼠屈光状态和眼球径的发展和比较[J]. 实验动物与比较医学, 2016, 24(1): 92-96 |
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| 作者姓名： | 卫振 张森 蒋丽琴 陈雁虹 吴凯 谢敏 刘迪文 谢强敏 |
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| 作者单位： | 浙江大学实验动物中心,温州医科大学,温州医科大学,浙江大学实验动物中心,浙江大学实验动物中心,浙江大学实验动物中心,浙江大学实验动物中心,浙江大学实验动物中心 |
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| 基金项目： | 浙江省公益性技术应用研究计划（2012C37085）;浙江省医药卫生科技计划（2014KYB074） |
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| 摘 要： | 【摘要】 目的 了解断奶后Zmu-1:DHP和DHP两个品系豚鼠屈光状态和眼球径的发展规律。方法 首先进行3周龄两品系豚鼠屈光检测，然后选择Zmu-1:DHP品系豚鼠12只，DHP品系8只，按品系分成两组。在4-12周龄，每隔一周检测屈光度、眼轴长和角膜曲率等参数。结果 3周龄，327只Zmu-1:DHP品系豚鼠，屈光度为-5.19?.92 D，近视率达85.1%；而117只DHP品系豚鼠屈光度为2.13?.40 D，近视率仅为22.6%。4-12周龄，Zmu-1:DHP品系豚鼠近视不断加深，屈光参差>1.5D；DHP品系豚鼠屈光发育稳定。T-检验，Zmu-1:DHP品系豚鼠眼轴长度、玻璃体腔深度显著高于DHP品系，视力低于DHP品系。多因素方差分析，Zmu-1:DHP品系豚鼠散光随时间变化显著（P＜0.01），而DHP品系不显著（P=0.07）。相关性分析，Zmu-1:DHP品系豚鼠屈光状态与眼轴长相关系数为-0.79（P＜0.01）、与玻璃体腔深度相关系数为-0.75（P＜0.01）；而DHP品系相应相关系数为-0.19（P=0.09）和-0.34（P＜0.01）。结论 Zmu-1:DHP品系豚鼠近视高发，正视化过程难以完成，其近视与眼轴长度和玻璃体腔深度高度相关。
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| 关 键 词： | 豚鼠；近视；屈光；眼轴长；角膜曲率 |
| 收稿时间： | 2015-11-04 |
| 修稿时间： | 2015-11-30 |
Comparison of the refractive development and ocular growth between two strains of guinea pigs |
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| WEI Zhen,ZHANG Sen,JIAGN Li-qin,CHEN Yan-hong,WU Kai,XIE Min,LIU Di-wen and XIE Qiang-min. Comparison of the refractive development and ocular growth between two strains of guinea pigs[J]. Laboratory Animal and Comparative Medicine, 2016, 24(1): 92-96 |
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| Authors: | WEI Zhen ZHANG Sen JIAGN Li-qin CHEN Yan-hong WU Kai XIE Min LIU Di-wen XIE Qiang-min |
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| Affiliation: | Laboratory Animal Center of Zhejiang University, Hangzhou 310058, China;Wenzhou Medical University, Wenzhou 325035;Wenzhou Medical University, Wenzhou 325035;Laboratory Animal Center of Zhejiang University, Hangzhou 310058, China;Laboratory Animal Center of Zhejiang University, Hangzhou 310058, China;Laboratory Animal Center of Zhejiang University, Hangzhou 310058, China;Laboratory Animal Center of Zhejiang University, Hangzhou 310058, China;Laboratory Animal Center of Zhejiang University, Hangzhou 310058, China |
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| Abstract: | Objective To compare the refractive development and axial eye growth between Zmu-1:DHP and DHP guinea pig strains after weaning. Methods After screening of the refractive status of two strains of guinea pigs at 3 weeks of age, twelve Zmu-1:DHP guinea pigs and eight DHP guinea pigs were chosen. Each group underwent a series of ocular measurements at five time-points (4, 6, 8, 10 and 12 weeks), including refraction, axial length, corneal curvature and other ocular parameters. Results The refraction of 3-week old Zmu-1:DHP strain(n=327)was-5.19±3.92 D with a myopic rate of 85.1%. While the refraction of DHP strain guinea pigs (n=117) was 2.13±4.40 D with a myopic rate of 22.6%. From 4 to 12 weeks of age, the guinea pigs of Zmu-1:DHP strain developed toward more myopic, their anisometropia was larger than 1.5 D. The DHP strain had a stable refractive state. The Zmu-1:DHP guinea pig strain had larger axial length and vitreous thickness than strain DHP (t-test: P<0.01), and the DHP guinea pig strain had better vision (P<0.01). Astigmatism of Zmu-1:DHP strain guinea pigs changed significantly from 4 to 12 weeks (ANOVA: P<0.01), while DHP strain did not (ANOVA: P =0.07). In the Zmu-1:DHP strain, the refractive status had significant correlation with axial length (r=-0.785, P<0.01) and vitreous chamber depth (r=-0.754, P<0.01). In the DHP strain, the correlation coefficients were-0.19(P =0.089)and-0.34 (P<0.01). Conclusions Zmu-1:DHP strain guinea pigs have a higher rate of spontaneous myopia than DHP strain. The emmetropization is disrupted. This myopia is highly correlated with axial length and vitreous chamber depth. |
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| Keywords: | Guinea pig Myopia Refraction Axial length Corneal curvature |
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