| 化疗后肿瘤微环境的变化与肿瘤转移的研究进展 |
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| 引用本文： | 吴瑞影,许建华. 化疗后肿瘤微环境的变化与肿瘤转移的研究进展[J]. 中国肿瘤临床, 2017, 44(20): 1049-1054. DOI: 10.3969/j.issn.1000-8179.2017.20.321 |
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| 作者姓名： | 吴瑞影 许建华 |
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| 作者单位： | 上海中医药大学附属普陀医院肿瘤科（上海市 200333） |
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| 基金项目： | 本文课题受国家自然科学基金(81573940)，上海市普陀区卫生系统自主创新科研项目(编号:15-PT-02)资助This work was supported by the National Natural Science Foundation of China(81573940)，the Independent Innovation Re-search Projects of Shanghai Putuo District Health Systems(15-PT-02) |
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| 摘 要： | 化疗旨在消灭肿瘤细胞，提高患者生存率，目前仍是恶性肿瘤治疗的主要手段之一，然而化疗后的复发转移是造成恶性肿瘤患者极高致死率的原因之一。现代研究认为，化疗药物作用于肿瘤细胞的同时，能引起一系列“宿主反应”，肿瘤微环境中相关组分产生变化，从而促进肿瘤的复发转移。本文就这些发生变化的主要组分进行综述。
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| 关 键 词： | 肿瘤 化疗 微环境 转移 |
| 收稿时间： | 2017-03-21 |
Research progress on chemotherapy-induced tumor microenvironment changes and tumor metastasis |
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| Ruiying WU,Jianhua XU. Research progress on chemotherapy-induced tumor microenvironment changes and tumor metastasis[J]. Chinese Journal of Clinical Oncology, 2017, 44(20): 1049-1054. DOI: 10.3969/j.issn.1000-8179.2017.20.321 |
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| Authors: | Ruiying WU Jianhua XU |
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| Affiliation: | Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200333, China |
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| Abstract: | Chemotherapy, which aims to kill tumor cells and improve the survival rate of patients, remains one of the main methods for treatment of malignant tumors. However, the regrowth and metastasis of tumor cells following chemotherapy is one of the rea-sons for high mortality rates in cancer patients. Modern research suggests that once chemotherapy drugs act on tumor cells, they also cause a series of host responses that may trigger many changes on related components in the tumor microenvironment, which can promote tumor recurrence and metastasis. This review focuses on research progress on the above changes. |
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| Keywords: | tumor chemotherapy microenvironment metastasis |
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