| 软组织肉瘤表观遗传学研究进展 |
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| 引用本文： | 张进明,马潇桐,冯和林.软组织肉瘤表观遗传学研究进展[J].中国肿瘤临床,2018,45(24):1277-1281. |
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| 作者姓名： | 张进明 马潇桐 冯和林 |
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| 作者单位： | 河北医科大学第四医院骨科（石家庄市050011） |
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| 基金项目： | 河北省自然基金面上项目H2015206314河北省医学科学研究重点计划20160159河北省医学科学研究重点计划20180511 |
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| 摘 要： | 软组织肉瘤是一组起源于间叶组织的恶性肿瘤，在成人恶性肿瘤中约占1%，但是其亚类繁多并且部分软组织肉瘤恶性程度较高，5年生存率为50%~60%。在不断探索软组织肉瘤发病机制的过程中，研究发现除了基因组变化可以致瘤，表观遗传学的改变与肿瘤的发生、发展也有着密切的联系。与遗传学不同，表观遗传学不涉及基因核苷酸序列的变化，主要通过DNA甲基化、组蛋白修饰、非编码RNA调控及染色质重塑等方式发生可遗传的基因表达。软组织肉瘤发生、发展过程中涉及的表观遗传学机制可以为临床诊断和治疗用药提供更多新思路。本文将对软组织肉瘤的表观遗传学研究进展进行综述。
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| 关 键 词： | 肉瘤 表观遗传学 软组织 |
| 收稿时间： | 2018-09-25 |
Advances in epigenetic research on soft tissue sarcomas |
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| Affiliation: | Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China |
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| Abstract: | Soft tissue sarcomas (STSs) are malignant tumors originating from mesenchymal tissues. They have lower morbidity rates than other cancers, which is only about 1% among adult malignancies. STSs consist of several subtypes and many of them are highly malignant. The 5-year survival rate is approximately 50%-60%. Investigation of STS pathogenesis demonstrated that epigenetic changes were closely related to the occurrence and development of STSs. Different from genetics changes, epigenetic changes are heritable and occur mainly through DNA methylation, histone modification, non-coding RNA regulation, and chromatin remodeling, all of which occur without changing the DNA sequence. Elucidation of the epigenetic mechanisms involved in STSs can help develop new clinical diagnosis and treatment methods, and this article aims to review the recent advances in epigenetic research on STS. |
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