| 雌激素与甲状腺癌相关性的研究进展 |
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| 引用本文： | 彭学姣,许天敏,张 琨,赵生炳,史 莹,常伟勤.雌激素与甲状腺癌相关性的研究进展[J].现代肿瘤医学,2018,0(11):1791-1794. |
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| 作者姓名： | 彭学姣 许天敏 张 琨 赵生炳 史 莹 常伟勤 |
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| 作者单位： | 吉林大学第二医院，吉林 长春 130041 |
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| 基金项目： | 吉林省科技厅项目资助（编号20160101043JC）；吉林省教育厅“十三五”科学技术研究项目资金资助项目（编号:吉教科合字［2016］第488号) |
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| 摘 要： | 甲状腺癌是最常见的内分泌肿瘤，近年来甲状腺癌的发病率有逐年递增趋势，其中甲状腺乳头状癌占80%以上，且男女发病率差异较大，这一现象引起了国内外学者的高度重视。很多研究都表明出现这样的性别差异可能与雌激素有关，雌激素可能在此过程中发挥着关键作用。雌激素与甲状腺癌的相关性研究是一个热点问题，目前已深入到各个研究层次，包括蛋白质及基因水平。探究雌激素在甲状腺癌发生发展过程中的作用及影响机制具有重要意义。因此本文通过查阅目前国内外研究报道就各研究层次雌激素与甲状腺癌的相关性进行综述。
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| 关 键 词： | 甲状腺癌 雌激素 雌激素受体 孕激素受体 雌激素代谢产物 上皮间质化 DNA甲基化 |
Research progress of the relationship between estrogen and thyroid cancer |
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| Peng Xuejiao,Xu Tianmin,Zhang Kun,Zhao Shengbing,Shi Ying,Chang Weiqin.Research progress of the relationship between estrogen and thyroid cancer[J].Journal of Modern Oncology,2018,0(11):1791-1794. |
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| Authors: | Peng Xuejiao Xu Tianmin Zhang Kun Zhao Shengbing Shi Ying Chang Weiqin |
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| Affiliation: | The Second Hospital of Jilin University，Jilin Changchun 130041，China. |
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| Abstract: | Thyroid cancer is the most common endocrine tumor.Recently，the incidence of thyroid cancer has increased year by year and more than 80% of thyroid carcinomas are papillary thyroid cancer，besides the incidence of male and female difference extremely.This phenomenon has attracted the attention of scholars both at home and abroad.Many studies have shown that this gender difference may be associated with estrogen.Estrogen may play an important part in the initiation of thyroid cancer.The study of the relationship between estrogen and thyroid cancer is a hot issue.It is now deep into various levels of research，including protein and gene levels.It is of great significance to explore the role and mechanism of estrogen in the occurrence and development of thyroid cancer.Therefore，the text reviews the correlation between estrogen and thyroid cancer at various levels by consulting the current domestic and foreign research reports. |
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| Keywords: | thyroid cancer estrogen estrogen receptor progesterone receptor estradiol metabolites epithelial to mesenchymal transition DNA methylation |
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