| 多中心型Castleman病临床病理分析并文献复习 |
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| 引用本文： | 张 玉1,景彩萍1,赵雪艳1,张桃桃1,霍媛媛1,张冠军2. 多中心型Castleman病临床病理分析并文献复习[J]. 现代肿瘤医学, 2018, 0(12): 1896-1899. DOI: 10.3969/j.issn.1672-4992.2018.12.023 |
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| 作者姓名： | 张 玉1 景彩萍1 赵雪艳1 张桃桃1 霍媛媛1 张冠军2 |
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| 作者单位： | 1.延安市人民医院病理科，陕西 延安 716000；2.西安交通大学第一附属医院病理科，陕西 西安 710061 |
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| 摘 要： | 目的:探讨多中心型Castleman病（multiple Castleman disease,MCD）的临床表现、病理学特征、鉴别诊断、病因及治疗，并分析其预后。方法:对9例多中心型Castleman病的临床资料、病理形态学特征进行分析，并行免疫组化检测及相关文献复习。结果:9例多中心型Castleman病例中，透明血管型5例，浆细胞型2例，透明血管浆细胞混合型2例。免疫组化无特征性表现，但可辅助诊断及鉴别诊断。9例多中心型患者均有完整随访资料，经治疗后其中有1例复发，1例死于心脏疾病，其余患者症状均有所缓解。结论:多中心型Castleman病是一种少见的淋巴组织增生性疾病，临床易与其他疾病相混淆，确诊需依靠病理学检查，准确的临床分型和病理类型对患者的治疗和预后具有重要意义。
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| 关 键 词： | 多中心 Castleman病 临床病理特征 免疫组化 病因 |
Clinicopathologic analysis of multicentric Castleman disease and review of the literature |
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| Zhang Yu1,Jing Caiping1,Zhao Xueyan1,Zhang Taotao1,Huo Yuanyuan1,Zhang Guanjun2. Clinicopathologic analysis of multicentric Castleman disease and review of the literature[J]. Journal of Modern Oncology, 2018, 0(12): 1896-1899. DOI: 10.3969/j.issn.1672-4992.2018.12.023 |
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| Authors: | Zhang Yu1 Jing Caiping1 Zhao Xueyan1 Zhang Taotao1 Huo Yuanyuan1 Zhang Guanjun2 |
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| Affiliation: | 1.Department of Pathology，People's Hospital of Yan'an，Shaanxi Yan'an 716000，China；2.Department of Pathology，the First Affiliated Hospital of Medical College of Xi'an Jiaotong University，Shaanxi Xi'an 710061，China. |
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| Abstract: | Objective:To investigate the clinic-pathologic features，differential diagnosis,etiology,treatment of multicentric Castleman disease，and analyze their prognosis.Methods:Retrospective analysis of the clinical features，pathological morphology,immunohistochemistry were conducted in 9 cases of multicentric Castleman disease and reviewed of literature．Results:There were 5 cases of hayline vascular types，2 cases of plasmatcyic type and 2 cases of mixed type in all multicentric Castleman disease． Immunohistochemical results had not specific change，but they can assist diagnosis and differential diagnosis.9 cases had complete follow-up data,1 case recurrened after treatment，1 case died of heart disease,other multicentric cases achieved sustained remission.Conclusion:Multicentric Castlemandisease is a rare lymphoproliferative lesion，it is easily confused with other diseases,identified diagnosis is depend on pathological examination.The accuracy of clinical subtype and histopathogenic type are important for treatment and outcome. |
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| Keywords: | multicentric Castleman disease clinicopathologic features immunohistochemistry etiology |
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