| 血浆D-二聚体水平与恶性肿瘤患者发生静脉血栓的相关性 |
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| 引用本文： | 王丽丽,刘 峰,张燕捷,袁海花,姜 斌. 血浆D-二聚体水平与恶性肿瘤患者发生静脉血栓的相关性[J]. 现代肿瘤医学, 2018, 0(9): 1427-1431. DOI: 10.3969/j.issn.1672-4992.2018.09.029 |
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| 作者姓名： | 王丽丽 刘 峰 张燕捷 袁海花 姜 斌 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院肿瘤科，上海 201999 |
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| 基金项目： | 上海市申康中心“促进市级医院临床技能与临床创新三年行动计划”项目（编号:16CR4030A） |
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| 摘 要： | 目的:观察血浆D-二聚体（D-dimer，D-D）水平对恶性肿瘤患者相关静脉血栓栓塞症（venous thromboembolism，VTE）发生的风险评估效果。方法:回顾性分析2016年1月至2017年1月本院新收住并经病理组织学证实的171例恶性肿瘤患者的临床资料，以初诊3个月内是否发生静脉血栓栓塞症（VTE）分为VTE组（32例）和非VTE组（139例），比较两组患者、不同临床分期患者、不同治疗方式患者、不同静脉血栓风险分层患者的血浆D-D值水平，采用Logistic多因素回归分析血浆D-D水平对恶性肿瘤患者相关VTE发生的风险评估效果。结果:VTE组的血浆D-D值水平显著高于非VTE组（P＜0.05），且随着恶性肿瘤临床分期的增加和静脉血栓风险分层的增高，该现象更加显著。Logistic多因素回归分析结果表明，化疗、手术、静脉血栓风险评估和血浆D-D水平是患者发生VTE的独立危险因素（P＜0.05）。结论:恶性肿瘤患者血浆D-D值水平明显升高，且与恶性肿瘤的临床分期和血栓风险分层相关；对恶性肿瘤患者进行血浆D-D值水平的检测，对预防恶性肿瘤患者初诊3个月内VTE的发生具有十分重要的参考意义。
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| 关 键 词： | 静脉血栓栓塞症 血浆D-二聚体 恶性肿瘤 |
The correlation between the level of plasma D-dimer and venous thromboembolism on cancer patients |
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| Wang Lili,Liu Feng,Zhang Yanjie,Yuan Haihua,Jiang Bin. The correlation between the level of plasma D-dimer and venous thromboembolism on cancer patients[J]. Journal of Modern Oncology, 2018, 0(9): 1427-1431. DOI: 10.3969/j.issn.1672-4992.2018.09.029 |
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| Authors: | Wang Lili Liu Feng Zhang Yanjie Yuan Haihua Jiang Bin |
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| Affiliation: | Department of Oncology，Shanghai Ninth People's Hospital，Shanghai Jiaotong University School of Medicine，Shanghai 201999，China. |
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| Abstract: | Objective:To investigate the value of the level of plasma D-dimer (D-D) in estimation of venous thromboembolism (VTE) risk on cancer patients.Methods:The clinical data of 171 cases of cancer patients registered in the Hospital from January 2016 to January 2017 were retrospectively analyzed，and divided into VTE group (n=32) and non-VTE group (n=139) according to the results of the first 3 months.The level of plasma D-D was compared between the VTE and non-VTE groups，among the patients with different clinical stages or venous thrombosis risk stratification.Multivariate Logistic regression analysis were performed to investigate the value of the level of plasma D-D in estimation of VTE risk on cancer patients.Results:VTE group of plasma D-D was significantly higher than the non-VTE group (P＜0.05)，and with the increase of the clinical stage and venous thrombosis risk levels，the phenomenon was more serious.Results of multivariate Logistic regression analysis showed that chemotherapy，surgery，venous thrombosis risk levels and plasma D-D level were the independent risk factors for VTE in the cancer patients (P＜0.05).Conclusion:The plasma D-D level is significantly increased in cancer patients，and is associated with the clinical stages and venous thrombosis risk levels.The detection of plasma D-D level in patients with malignant tumor is very important for the prevention of malignant tumor in 3 months. |
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| Keywords: | venous thromboembolism plasma D-dimer (D-D) cancer |
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