| ZO-1 SNPs与胃癌遗传易感性及预后* |
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| 引用本文： | 郑珂,张声,陈林莺,王行富,陈虹,张真真,陈余鹏.ZO-1 SNPs与胃癌遗传易感性及预后*[J].中国肿瘤临床,2010,37(22):1278-1281. |
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| 作者姓名： | 郑珂 张声 陈林莺 王行富 陈虹 张真真 陈余鹏 |
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| 作者单位： | 作者单位:福建医科大学附属第一医院病理科(福州市350005) |
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| 基金项目： | 本文课题受福建医科大学学科带头人基金资助 |
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| 摘 要： | 目的:探讨中国福建地区汉族人群中ZO- 1 基因TJP1 4 个已知位点单核苷酸多态性（SNPs）与胃癌遗传易感性及进展和预后的相关性。方法:应用PCR-LDR法检测福建医科大学附属第一医院200 例健康体检个体及220 例原发性胃腺癌患者TJP1基因4 个SNP 位点的基因型。结果:福建地区汉族人群中，TJP-1 SNP rs 7179270 位点稀有等位基因C 的频率为0.2，而其他三个位点（rs 34771010，rs 28578444和rs 41280058）稀有等位基因频率为0.0。TJP1 基因SNP 位点rs 7179270 200 例对照组等位基因C、T 的频率分别为20% 和80% ，胃癌病例组等位基因C、T 的频率为32.6% 和67.4% ；CC、C/T和TT的基因型频率在对照组分别为4% 、32%和64% ，而在病例组为10.9% 、43.2% 和45.9% ，差异具有统计学意义（OR= 1.953，95%CI 1.425～2.677，P<0.001）。 TJP1 rs 7179270位点基因型与胃癌患者的性别、年龄、分化程度、浸润深度、淋巴结转移及手术后生存时间无显著相关（P>0.05）。 结论:TJP1rs 7179270 位点携带等位基因C 的CC和C/T基因型个体的胃癌患病风险提高，提示检测该位点基因型有助于评估胃癌的遗传易感性；TJP1 rs 7179270 位点的基因型频率与临床病理学参数及胃癌患者手术后生存时间无显著相关性，提示TJP1 rs 7179270 位点多态性可能不参与胃癌的进展和预后；TJP1 rs 34771010、rs 28578444和rs 41280058稀有等位基因频率为0.0，推测中国福建地区人群可能无这三个位点的多态性分布。
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| 关 键 词： | 胃癌 ZO- 1? TJP1? SNP? 易感性 预后 |
| 收稿时间： | 2010-03-31 |
Relationship of ZO-1 SNP Polymorphisms with Susceptibility and Prognosis of Gastric Cancer |
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| ZHENG Ke,ZHANG Sheng,CHEN Linying,WANG Xingfu,CHEN Hong,ZHANG Zhenzhen,CHEN Yupeng.Relationship of ZO-1 SNP Polymorphisms with Susceptibility and Prognosis of Gastric Cancer[J].Chinese Journal of Clinical Oncology,2010,37(22):1278-1281. |
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| Authors: | ZHENG Ke ZHANG Sheng CHEN Linying WANG Xingfu CHEN Hong ZHANG Zhenzhen CHEN Yupeng |
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| Affiliation: | Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China |
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| Abstract: | Objective: To investigate the relationship of four known single nucleotide polymorphisms (SNPs) of the TJP 1 gene with susceptibility and prognosis of gastric carcinoma in a Fujian Chinese Han cohort. Methods:TJP 1 gene 4 SNP loci genotypes of 200 healthy people and 220 gastric carcinoma patients were assayed using PCR-based LDR analy-sis. Results: The frequency of rare allele C in the TJP1 SNP rs7179270 locus was 0.2, while the frequency of rare allele in the other three SNP loci (rs 34771010, rs 28578444, rs 41280058) was 0.0. The frequencies of C and T alleles and CC, CT, TT genotypes at the TJP 1 rs 7179270 locus were significantly different between patients with gastric carcinoma and the con -trol groups (OR= 1.953 , 95% CI1.425 -2.677 , P<0.001 ). These frequencies were not significantly related to sex, age, degree of differentiation, depth of invasion, lymph node metastasis or survival in patients with gastric carcinoma (P>0.05). Conclusion:Individuals with CC and CT genotypes at the TJP 1 rs 7179270 locus have increased risk of gastric carcinoma, suggest -ing that screening for this genotype would be helpful in assessing the genetic susceptibility of gastric carcinoma. The fre -quency of these genotypes is not significantly related to clinicopathologic parameters or survival in gastric carcinomas, sug-gesting that TJP1 rs 7179270 polymorphism may not be involved in the progress and prognosis of gastric carcinoma. |
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| Keywords: | ZO-1 TJP1 SNP |
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