| 人参低聚肽对急性酒精性肝损伤大鼠的保护作用 |
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| 引用本文： | 刘睿,任金威,陈启贺,孙彬,李迪,毛瑞雪,蔡夏夏,何丽霞,李勇. 人参低聚肽对急性酒精性肝损伤大鼠的保护作用[J]. 现代预防医学, 2016, 0(15): 2820-2824 |
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| 作者姓名： | 刘睿 任金威 陈启贺 孙彬 李迪 毛瑞雪 蔡夏夏 何丽霞 李勇 |
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| 作者单位： | 北京大学医学部公共卫生学院营养与食品卫生学系,北京 100191 |
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| 摘 要： | 目的 探讨人参低聚肽（GOP）对酒精诱导的大鼠急性肝损伤的保护作用及其可能机制。方法 采用SPF级SD雄性大鼠,随机分为7组,每组10只,包括，1个空白对照组、1个模型对照组、1个乳清蛋白对照组（0.250 0 g/kg）和4个GOP剂量组(0.062 5、0.125 0、0.250 0、0.500 0 g/kg)。连续灌胃30d后,采用体积分数 50%的酒精以 7g/(kg·BW)剂量灌胃造成大鼠急性酒精性肝损伤模型,测定大鼠血清ALT、AST活性和肝脏SOD、GSH、GSH-PX及MDA含量。结果 与模型对照组相比,GOP干预可以显著降低大鼠血清ALT、AST和肝组织MDA(P<0.05或P<0.01)的水平,增加肝组织SOD 、GSH和GSH-PX的活性（P<0.05或P<0.01)。结论 GOP对酒精诱导引起的大鼠急性肝损伤具有保护作用,其机制可能与提高机体抗氧化水平有关。
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| 关 键 词： | 人参低聚肽 急性酒精性肝损伤 氧化应激 脂质过氧化 |
Protective effects of panax ginseng oligopeptide on acute alcohol-induced liver injury and underlying mechanism |
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| LIU Rui,REN Jin-wei,CHEN Qi-he,SUN Bin,LI Di,MAO Rui-xue,CAI Xia-xia,HE Li-xia,LI Yong. Protective effects of panax ginseng oligopeptide on acute alcohol-induced liver injury and underlying mechanism[J]. Modern Preventive Medicine, 2016, 0(15): 2820-2824 |
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| Authors: | LIU Rui REN Jin-wei CHEN Qi-he SUN Bin LI Di MAO Rui-xue CAI Xia-xia HE Li-xia LI Yong |
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| Affiliation: | Department of Nutrition and Food Hygiene,School of Public Health,Peking University Health Science Center,Beijing 100191,China |
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| Abstract: | Objective To investigate the effects and mechanism of panax ginseng oligopeptide(GOP)on acute alcohol-induced Liver injury in rats. Methods A total of 70 SD rats were randomly assigned to 7 groups,including a normal control group,a model group,a whey protein group(0.2500 g/kg),and 4 GOP intervention groups (0.0625,0.1250,0.2500,0.5000 g/kg).7 g/kg/BW 50% v ethanol was given intragastricly after the 30 days of rat stomach-lavaging continuously,serum markers were assayed,and the oxidative stress and lipid peroxidation parameters in liver tissue were conducted. Results We found that the GOP treatment prevented the elevation of serum aminotransferase,and SOD,GSH,GSH-PX contents in all test groups were increased significantly (P<0.05 or P<0.01).In addition,MDA contents decreased significantly in all GOP prevention groups (P<0.01). Conclusion These findings suggest that GOP have a significant protective effect on acute alcohol-induced Liver injury in rats,and the underlying mechanism may be related to enhancing anti-oxidative activities. |
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| Keywords: | Panax ginseng oligopeptide Acute alcohol-induced Liver injury Oxidative stress Lipid peroxidation |
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