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| 孕酮诱导核心蛋白聚糖在子宫内膜异位症组织中的表达及其意义 | |
| 引用本文： | 李晋琼,申向东. 孕酮诱导核心蛋白聚糖在子宫内膜异位症组织中的表达及其意义[J]. 现代预防医学, 2016, 0(13): 2489-2492 |
| 作者姓名： | 李晋琼 申向东 |
| 作者单位： | 山西省长治医学院附属和济医院妇产科,山西 长治 046000;山西省长治医学院病理科,山西 长治 046000 |
| 摘 要： | 目的 检测孕酮对人异位子宫内膜上皮细胞和基质细胞的直接影响,并评价其如何影响核心蛋白聚糖（DCN）在异位子宫内膜上皮细胞和基质细胞的表达,探讨DCN对治疗子宫内膜异位症的作用。方法 2013年6月-2014年7月间就诊的子宫内膜异位症患者共60例,将其分为2组,一组为术前给予孕激素治疗6个月（甲羟孕酮组）,另一组术前未接受任何药物治疗（未治疗组）,60例患者均经手术治疗。另随机选择非子宫内膜异位症患者24例作为阴性对照（对照组）,术中切除标本后立即取材,经免疫组化染色等步骤制作好切片后,在光镜下进行结果判定。结果 免疫组化结果显示,DCN在经孕酮治疗的子宫内膜异位组织中与未经孕酮治疗的子宫内膜异位组织中相比呈现高表达。其中,非子宫内膜异位症患者子宫内膜细胞及间质细胞全部为DCN阴性表达;未治疗组6例内膜细胞DCN呈不同程度阳性表达,占20.0%,4例间质细胞DCN呈不同程度阳性表达,占13.3%;甲羟孕酮组26例内膜细胞呈不同程度DCN阳性表达,占86.7%,24例间质细胞呈不同程度DCN阳性表达,占80.0%。结论 经孕激素治疗的子宫内膜异位病灶中DCN呈现高表达,推测孕酮诱导DCN高表达、并通过高水平DCN达到对子宫内膜异位症的治疗作用。 |
| 关 键 词： | 核心蛋白聚糖 孕酮 子宫内膜异位症 |
Progesterone-induced decorin expression and its significance in endometriosis tissue |
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| LI Jin-qiong,SHEN Xiang-dong. Progesterone-induced decorin expression and its significance in endometriosis tissue[J]. Modern Preventive Medicine, 2016, 0(13): 2489-2492 | |
| Authors: | LI Jin-qiong SHEN Xiang-dong |
| Affiliation: | Department of Pathology,Changzhi Medical College,Changzhi,Shanxi 046000,China |
| Abstract: | Objective To detect the direct effects of progesterone on human epithelial and stromal cells of endometriosis,to evaluate how they influence the expression of decorin(DCN)on epithelial and stromal cells in the ectopic endometrium,and to evaluate the therapeutic effects of DCN for endometriosis. Methods 60 cases of endometriosis were collected from June 2013 to July 2014,which were divided into two groups. One group of patients was given administering progestin therapy for six months before pre-operation(medroxyprogesterone acetate group),while the other group of patients did not receive any treatment(untreated group). All 60 patients were treated by surgery. Another random selection of 24 patients without endometriosis was as the negative control(control group). During the operation the specimens were resected,then with immediately drawing materials. After immunohistochemical staining procedure for creating good slices,the results were determined by using the light microscope. Results Immunohistochemistry showed,Compared with the non-treatment of progesterone,DCN showed high expression on endometriosis tissue after the progesterone treatment. The normal endometrial cells and interstitial cells all presented negative expression on DCN among patients of endometriosis. In the untreated group,6 cases of endometrial cells showed varying degrees of positive expression on DCN,accounting for 20.0%. Different levels of expression between 4 cases of interstitial cells of DCN were accounted for 13.3%. Medroxyprogesterone acetate group of 26 patients were positive for endometrial cells with expressing different degrees of DCN,accounting for 86.7%,and 24 positive cases of interstitial cells for 80.0%. Conclusion After progestogen therapy,DCN in endometriosis lesions shows high expression,and speculates that the progesterone induces the expression of DCN and the high levels of DCN achieve the therapeutic action of endometriosis. |
| Keywords: | Decorin Progesterone Endometriosis |
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