| Clinical Pathologic Study on Effect of Qianggan Capsule (强肝胶囊) in Treating Patients of Chronic Hepatitis B with Liver Cirrhosis |
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| 引用本文： | 杨柳明,赵延龙,吴志荣,陈杜芳,岑卓英,徐克成,左建生,危北海,张万岱. Clinical Pathologic Study on Effect of Qianggan Capsule (强肝胶囊) in Treating Patients of Chronic Hepatitis B with Liver Cirrhosis[J]. 中国结合医学杂志, 2002, 8(2) |
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| 作者姓名： | 杨柳明 赵延龙 吴志荣 陈杜芳 岑卓英 徐克成 左建生 危北海 张万岱 |
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| 作者单位： | 杨柳明,赵延龙,吴志荣,陈杜芳,岑卓英(Department of Liver Diseases, Institute of Integrated Chinese Traditional and Western Medicine, Lianjiang City, Guangdong Province 524400);徐克成,左建生(Yanghe Medical Center, Shenzheng);危北海(Beijing Municipal Institute of TCM);张万岱(South Hospital Affiliated to the First Medical University of PLA) |
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| 基金项目： | ItemofthekeyprogramofScienceandTechniqueofZhan jiangCity(No.2 0 0 0 6 8) |
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| 摘 要： |
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Clinical Pathologic Study on Effect of Qianggan Capsule (强肝胶囊)in Treating Patients of Chronic Hepatitis B With Liver Cirrhosis |
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| Abstract: | Objective: To explore the clinical therapeutic effect of Qianggan Capsule (QGC) in treating chronic hepatitis B with liver fibrosis from the pathological aspect. Methods: Sixty-three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group (n=45) and the control group (n=18). Both groups were treated with general liver protective drugs, such as Glucurone and vitamins B complex for 6 months. To the treated group, QGC was used additionally. The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid (HA), collagen type Ⅳ (C-Ⅳ) and laminin (LN) as well as the pathological examination of liver biopsy were observed before and after treatment. Results: The liver cirrhosis indexes, HA, C-Ⅳ and LN, were improved significantly in the treated group after treatment, P<0.05. The liver function improvement rate in the treated group and the control group was 90.3% and 66.7% respectively, comparison of the two groups showed insignificant difference, P>0.05. Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57.8% and that on liver fibrosis stage was 75.6%, which were significantly improved as compared with those before treatment (P<0.05 and P<0.01), while in the control group, no significant improvement was found after treatment (P>0.05). Conclusion: QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis, and could lower the serum liver fibrosis related indexes effectively. |
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| Keywords: | Qianggan Capsule chronic hepatitis B liver fibrosis pathology |
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