| 瑞香素杀疟原虫裂殖体的作用 |
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| 引用本文： | 王琴美,倪奕昌,徐月琴,哈淑华,蔡玥.瑞香素杀疟原虫裂殖体的作用[J].中国寄生虫学与寄生虫病杂志,2000,18(4):204-206. |
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| 作者姓名： | 王琴美 倪奕昌 徐月琴 哈淑华 蔡玥 |
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| 作者单位： | 中国预防医学科学院寄生虫病研究所** 上海 200025 |
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| 基金项目： | Supported by Chinese
Academy of Preventive Medicine WHO Collaborating Center for Malaria, Schistosomiasis and
Filariasis |
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| 摘 要： | 目的 ]研究中药瑞香素在体外和体内的杀裂殖体作用。 方法 ]在恶性疟原虫FCCl株常规体外培养中测试瑞香素杀裂殖体活性 ,并按“四天抑制性试验”在感染伯氏疟原虫ANKA株的小鼠中测定不同剂量瑞香素的体内抗疟活性。 结果 ]体外试验中瑞香素在 1～ 10 μmol L剂量范围内有明显杀灭裂殖体作用 ,而体内试验中按D4减虫率与感染鼠在 30d内的平均生存天数评价 ,5 0或 10 0mg kg .d- 1 × 4d瑞香素灌胃以及 10 ,5 0或 10 0mg kg.d- 1 × 4d瑞香素腹腔注射给药在伯氏鼠疟原虫ANKA株感染鼠中的抗疟作用与 10mg kg .d- 1 × 4d氯喹 (CQ)灌胃的疗效相似。 结论 ]瑞香素在体外和体内均有一定的杀裂殖体作用。
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| 关 键 词： | 瑞香素 恶性疟原虫 伯氏疟原虫 杀裂殖体活性 |
| 文章编号： | 1000-7423(2000)-04-0204-03 |
| 修稿时间： | 2000年2月22日 |
THE SCHIZONTOCIDAL ACTIVITY OF DAPHNETIN AGAINST MALARIA PARASITES IN VITRO AND IN VIVO |
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| WANG Qin-mei,NI Yi-chang,XU Yue-qin,HA Shu-hua,CAI Yue.THE SCHIZONTOCIDAL ACTIVITY OF DAPHNETIN AGAINST MALARIA PARASITES IN VITRO AND IN VIVO[J].Chinese Journal of Parasitology and Parasitic Diseases,2000,18(4):204-206. |
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| Authors: | WANG Qin-mei NI Yi-chang XU Yue-qin HA Shu-hua CAI Yue |
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| Affiliation: | Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025. |
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| Abstract: | OBJECTIVE: To investigate the in vitro and in vivo schizontocidal activity of daphnetin. METHODS: Schizontocidal activity of daphnetin was tested using an in vitro assay based on the routine in vitro cultivation of P. falciparum FCC1 strain. The in vivo antimalarial effects of daphnetin at various dosages were assessed in mice infected with P. b. erghei ANKA according to "4-day suppress assay". RESULTS: In vitro, daphnetin exhibited potent schizontocidal activity comparable to chloroquine(CQ) at the dose range of 1-10 mumol/L. In vivo, 50 or 100 mg/kg.d-1 x 4 d daphnetin i.g. and 10, 50 or 100 mg/kg.d-1 x 4 d dephnetin i.p. showed antimalarial efficacy comparable to CQ 10 mg/kg.d-1 x 4 d i.g. in mice infected with P. berghei ANKA, evaluated by both the reduction rate of parasitemia on D4 and the average surviving days in 30 days. CONCLUSION: Daphnetin displays certain schizontocidal activity both in vitro and in vivo. |
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| Keywords: | daphnetin Plasmodium falciparum Plasmodium berghei schizontocidal activity |
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