Correlation of obstructive sleep apnea hypopnea syndrome with metabolic syndrome in snorers |
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| Authors: | Qun Zhang Xiaofeng Zhang Mengmeng Zhao Hanpeng Huang Ning Ding Xilong Zhang Hong Wang |
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| Affiliation: | 1.Nanjing Medical University, Nanjing, Jiangsu 210029, China2.Department of Respiratory Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China |
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| Abstract: | Though obstructive sleep apnea hypopnea syndrome (OSAHS) and metabolic syndrome (MS) are correlated; the contributing factors for the occurrence of MS in Chinese snorers remain largely undefined. We aimed to investigate the associated pathogenesis of coexistence of OSAHS and MS in Chinese snorers. A total of 144 Chinese habitual snorers were divided into 3 groups, the control group (simple snorers) (n = 36), the mild OSAHS group (n = 52) and the moderate-to-severe OSAHS group (n = 56). The incidence of MS in the moderate-to-severe OSAHS group (26.8%) was significantly higher than that in the control group (8.3%), the mild OSAHS group (11.1%) and all the OSAHS patients (19.45%) (all P < 0.05). Homeostatic model assessment (HOMA) index and proinsulin (PI) were negatively correlated with nocturnal meanSpO2 and miniSpO2. Meanwhile, nocturnal SpO2 were negatively correlated with body mass index, waist and neck circumferences and diastolic blood pressure, but positively correlated with total cholesterol and high-density lipoprotein cholesterol. The study indicated that in Chinese snorers, moderate-to-severe OSAHS was closely associated with MS via nocturnal hypoxemia. |
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| Keywords: | hypoxia insulin resistance metabolic syndrome obstructive sleep apnea hypopnea syndrome |
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