| 临床患者血清CK-MB活性大于总肌酸激酶活性的生物学特征及原因分析 |
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| 引用本文： | 张 鹏,迟 洁,白香妮,王银坤,郑 霄,刘文康.临床患者血清CK-MB活性大于总肌酸激酶活性的生物学特征及原因分析[J].现代检验医学杂志,2021,0(6):116-119. |
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| 作者姓名： | 张 鹏 迟 洁 白香妮 王银坤 郑 霄 刘文康 |
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| 作者单位： | （1.西安工会医院检验科，西安710100；2.陕西省人民医院检验科，西安 710068；3.西电集团医院，西安 710077） |
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| 摘 要： | 目的 回顾性分析血清肌酸激酶同工酶（creatine kinase-MB，CK-MB）活性大于总肌酸激酶(creatine kinase，CK)活性的患者生物学特征及其原因。方法 选取2017～2018年陕西省人民医院住院部29 993例住院患者为研究对象，使用全自动生化分析仪速率法检测血清CK活性和免疫抑制法检测血清CK-MB活性，用统计学方法分析CK-MB>CK患者的生物学特征及产生的原因。结果 在29 993例患者中血清CK-MB>CK占0.81%（242/29 993）。总体上在各年龄段中血清CK-MB>CK患者人数差异有统计学意义（χ2=60.626，P=0.000），而且在各年龄段之间血清CK-MB>CK的男性和女性患者人数差异均有统计学意义（χ2=24.787，46.206，均P=0.000）；＜15岁患者中血清CK-MB＞MB人数最多。血清CK-MB＞CK男性患者人数少于女性患者人数（45.87% vs 54.13%），差异具有统计学意义（χ2=13.099，P=0.022），其中15~30岁组男性患者人数明显少于女性患者，差异有统计学意义（χ2=6.962，P=0.008），其他年龄段男女患者人数差异无统计学意义（χ2=0.249~3.931，均P＞0.05）。血清CK-MB＞CK患者所患疾病中，感染性疾病占44.2%（107/242），恶性肿瘤占20.7%（50/242），其他疾病共占35.1%（85/242）。结论 明确血清CK-MB＞CK患者生物学特征及与所患疾病的关系，有助于临床鉴别诊断相关疾病。
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| 关 键 词： | 肌酸激酶活性（CK） 肌酸激酶同工酶（CK-MB） 生物学特征 |
Biological Characteristics and Cause Analysis of Clinical Patients with Serum CK-MB-to-Total-CK Ratio More Than 1.0 |
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| ZHANG Peng,CHI Jie,BAI Xiang-ni,et al.Biological Characteristics and Cause Analysis of Clinical Patients with Serum CK-MB-to-Total-CK Ratio More Than 1.0[J].Journal of Modern Laboratory Medicine,2021,0(6):116-119. |
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| Authors: | ZHANG Peng CHI Jie BAI Xiang-ni |
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| Affiliation: | （1.Department of Clinical Laboratory, Xi’an Trade Union Hospital, Xi’an 710100, China；2.Department of Clinical Laboratory, Shaanxi Provincial People’s Hospital, Xi’an 710068, China；3.Department of Clinical Laboratory, Xi’an XD Group Hospital, Xi’an 710077，China） |
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| Abstract: | Objective Retrospective analysis on biological characteristics of patients with serum CK-MB-to-total-CK ratio more than 1.0 (CK-MB>CK) was performed. Methods 29 993 patients were recruited from inpatient departments of Shaanxi Provincial Hospital from January 2017 to December 2018. Serum CK activity and CK-MB activity were detected by automatic biochemical analyzer with rate method and immunosuppression methods, respectively. Results The patients with serum CK-MB>CK accounted for 0.81% (242/29 993). Generally, there existed statistical differences for the number of patients with serum CK-MB>CK between age groups（χ2=60.626, P=0.000）. There existed significantly statistical difference between age groups for male patients with serum CK-MB>CK (χ2=24.787，P=0.000) as well as female ones （χ2=46.206，P=0.000）.There were the most male patients with CK-MB>CK younger than 15 years old as well as female ones（45.87% vs 54.13%）. The male patients with CK-MB>CK was statistically less than that of female ones，the difference was significantly statistical（χ2=13.099，P=0.022）. The female patients aged from 10 to 15 years old with CK-MB>CK were more than those of male ones (χ2=6.962，P=0.008) and there were no statistical differences between other age groups（χ2=0.249~3.931，all P>0.05）. 44.2% (107/242) of patients with serum CK-MB>CK had infectious diseases, 20.7% (50/242) malignant tumors and 35.1% (85/242) other diseases. Conclusion The investigation was helpful for further understanding biological characteristics of patients with serum CK-MB>CK and clinical differential diagnosis. |
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