| 化疗对晚期食管癌患者细胞免疫及调节T细胞的影响 |
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| 引用本文： | 廖娟,周云峰.化疗对晚期食管癌患者细胞免疫及调节T细胞的影响[J].现代临床医学,2014,40(1):32-34. |
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| 作者姓名： | 廖娟 周云峰 |
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| 作者单位： | 川北医学院附属医院消化科,川北医学院附属医院消化科 |
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| 摘 要： | 目的:探讨晚期食管癌患者化疗前后细胞免疫及调节T细胞(tregs)的变化及其临床价值。方法:采用流式细胞术检测健康志愿者及食管癌患者化疗前后外周血CD4+T、CD8+T细胞及调节T细胞的比例变化。结果:晚期食管癌患者化疗前外周血CD4+T细胞所占比例和CD4+T/CD8+T均较化疗后低,且二者均低于健康对照组(P<0.05)。晚期食管癌患者CD4+CD25+T细胞和Tregs细胞所占比例化疗后较化疗前有所降低,二者均明显高于健康对照组。结论:化疗能明显减轻晚期食管癌患者的肿瘤免疫耐受,改善免疫状况。
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| 关 键 词： | 免疫调节T细胞 食管癌 化疗 细胞免疫 |
| 收稿时间： | 2013/7/26 0:00:00 |
| 修稿时间： | 2014/1/28 0:00:00 |
Effect of Chemotherapy on Cellular Immune Function and Tregs in Patients with Advanced Esophageal Cancer |
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| LIAO Juan and ZHUO Yunfeng.Effect of Chemotherapy on Cellular Immune Function and Tregs in Patients with Advanced Esophageal Cancer[J].Journal of Modern Clinical Medicine,2014,40(1):32-34. |
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| Authors: | LIAO Juan and ZHUO Yunfeng |
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| Affiliation: | Liao Juan;Zhou Yunfeng;North Sichuan Medical College Affiliated Hospital; |
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| Abstract: | Objective:To investigate the changes of cellular immune function and CD4 CD25 regulatory T cells (Tregs) in peripheral blood of patients with advanced esophageal cancer before and after chemotherapy and their clinical implications. Methods:The proportion of CD4 CD25 Tregs among CD4 T lymphocytes and the proportion of CD4 and CD8 T cells of PBMC in peripheral blood of 32 patients with advanced esophageal cancer was determined by flow cytometry before 1 day and 1 week after chemotherapy.Results:Compared with control group,the levels of CD4 T lymphocytes and CD4 /CD8 T lymphocytes decreased in patients with advanced esophageal cancer before and after chemotherapy,but the data after treatment was higher than before. The percentage of CD4 CD25 T cells and Tregs among CD4 T lymphocytes significantly changed after chemotherapy as compared with that before chemotherapy, the difference was significant between the patients and the healthy subjects.Conclusion: chemotherapy can improve the immune function of patients with advanced esophageal cancer. |
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| Keywords: | immunoregulatory cells esophageal cancer chemotherapy cellular immunity |
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