Bactericidal activity of ramoplanin against antibiotic-resistant enterococci. |
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| Authors: | C C Johnson S Taylor P Pitsakis P May M E Levison |
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| Affiliation: | Medical College of Pennsylvania, Philadelphia 19129. |
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| Abstract: | ![]()
Ramoplanin, a new lipoglycodepsipeptide antibiotic, was uniformly active against 65 strains of enterococci, including strains highly resistant to vancomycin, penicillin G, and gentamicin. MBCs were usually within a fourfold dilution of the MICs. In time-kill studies, ramoplanin alone demonstrated dose-dependent bactericidal activity against enterococcal strains that resisted killing by vancomycin or penicillin in combination with gentamicin. |
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