Structural diversity of streptokinase and activation of human plasminogen |
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| Authors: | Lizano Sergio Johnston Kenneth H |
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| Affiliation: | Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA. sergio_lizano@nymc.edu |
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| Abstract: | ![]()
The beta domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease. |
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