| 乙型肝炎性肝癌和酒精相关性肝癌患者外周血中T细胞亚群表达差异和价值 |
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| 引用本文： | 黄国定,卢宏全,潘敏丽,吕琼秀.乙型肝炎性肝癌和酒精相关性肝癌患者外周血中T细胞亚群表达差异和价值[J].现代肿瘤医学,2021,0(9):1547-1550. |
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| 作者姓名： | 黄国定 卢宏全 潘敏丽 吕琼秀 |
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| 作者单位： | 海南西部中心医院肿瘤内科,海南 儋州 571700 |
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| 摘 要： | 目的:分析乙型肝炎性肝癌（HBV-HCC）和酒精相关性肝癌（ALC-HCC）患者外周血中T 细胞亚群表达差异和价值。方法:将2016年07月至2018年10月期间于本院接受诊治的65例乙型肝炎性肝癌患者作为HBV-HCC组，另选择同期于本院接受诊治的58例酒精相关性肝癌患者作为ALC-HCC组。经全自动生化分析仪及流式细胞仪对两组患者的T细胞亚群指标表达情况进行检测，并对比分析两组患者的肝功能Child-Pugh分级。结果:两组患者的肝功能Child-Pugh分级对比，差异无统计学意义（P＞0.05）；HBV-HCC组患者外周血中CD3+、CD8+、CD4+CD45RA+值高于ALC-HCC组，但外周血中CD4+、CD4+/CD8+、CD4+CD25+、CD8+CD28+值低于ALC-HCC组，差异有统计学意义（P＜0.05）；单因素分析发现，患者年龄、BMI、手术类型、临床分期、原发病灶大小、血管浸润及生存时间中位数与患者预后存在相关性，差异有统计学意义（P＜0.05）；多因素Logistic回归分析发现，患者年龄≥60岁、BMI＞24 kg/m2、开腹手术、临床分期、原发病灶＞3.6 cm、血管浸润及生存时间中位数＜72个月是影响患者生存质量的独立因素，差异有统计学意义（P＜0.05）。结论:乙型肝炎性肝癌和酒精相关性肝癌患者外周血中T 细胞亚群表达具有明显差异，能视作临床评判肝癌患者病情演变及疗效、预后的重要指标。
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| 关 键 词： | 乙型肝炎性肝癌 酒精相关性肝癌 T细胞亚群 肝功能 预后康复质量 |
Differential expression and value of T cell subsets in peripheral blood of patients with hepatitis B and alcohol-related liver cancer |
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| HUANG Guoding,LU Hongquan,PAN Minli,LYU Qiongxiu.Differential expression and value of T cell subsets in peripheral blood of patients with hepatitis B and alcohol-related liver cancer[J].Journal of Modern Oncology,2021,0(9):1547-1550. |
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| Authors: | HUANG Guoding LU Hongquan PAN Minli LYU Qiongxiu |
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| Affiliation: | Department of Oncology,Hainan Western Central Hospital,Hainan Danzhou 571700,China. |
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| Abstract: | Objective:To analyze the differential expression and value of T cell subsets in peripheral blood of patients with hepatitis B(HBV-HCC)and alcohol-related liver cancer(ALC-HCC).Methods:65 cases of patients with hepatitis B liver cancer who were treated in our hospital from July 2016 to October 2018 were treated as HBV-HCC group.Another 58 cases of patients with alcohol-related liver cancer who were treated in our hospital at the same time were selected as the ALC-HCC group.The T cell subsets were detected by automatic biochemical analyzer and flow cytometry.The Child-Pugh classification of liver function was compared between the two groups.Results:The values of CD3+,CD8+,CD4+CD45RA+in peripheral blood of HBV-HCC group were higher than those in ALC-HCC group,but the values of CD4+,CD4+/CD8+,CD4+CD25+,CD8+CD28+in peripheral blood were lower than those in ALC-HCC group(P<0.05).Univariate analysis showed that the age,BMI,type of surgery,clinical stage,size of primary lesion,size of vascular invasion and survival time were correlated with the prognosis of patients(P<0.05).Multivariate Logistic regression analysis found that patients aged≥60 years old,BMI>24 kg/m2,open surgery,clinical stage,primary lesion>3.6 cm,vascular invasion and median survival time<72 months were factors influencing prognosis(P<0.05).Conclusion:The expression of T cell subsets in peripheral blood of patients with hepatitis B and alcohol-related liver cancer are significantly different,which can be regarded as an important index for clinical evaluation of the disease progression,efficacy and prognosis of liver cancer patients. |
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| Keywords: | hepatitis B alcohol-related liver cancer T cell subset liver function prognosis quality |
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