Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan |
| |
| Authors: | Chen Kow-Tong Twu Shiing-Jer Chang Hong-Jen Lin Ruey-Shiung |
| |
| Affiliation: | Field Epidemiology Training Program, Center for Disease Control, Department of Health, Taipei, Taiwan, Republic of China. |
| |
| Abstract: | ![]()
OBJECTIVES: This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan. METHODS: Forty-six SJS/TEN patients were matched to 92 controls according to month of arrival in Taiwan, sex, and age. RESULTS: The odds ratio for development of SJS/TEN was 9.5 (95% confidence interval [CI] = 3.9, 23.9) among workers who had used both metronidazole and mebendazole sometime in the preceding 6 weeks. In addition, a gradient increase in the occurrence of SJS/TEN was found with an increasing level of exposure to metronidazole. CONCLUSIONS: This outbreak highlights the risk of SJS/TEN resulting from the use of both metronidazole and mebendazole and the need for control measures. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
