| 肝X受体与肝癌研究进展 |
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| 引用本文： | 邵存华,郭兴军.肝X受体与肝癌研究进展[J].现代肿瘤医学,2021,0(4):700-703. |
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| 作者姓名： | 邵存华 郭兴军 |
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| 作者单位： | 东营市人民医院肝胆外科，山东 东营 257091 |
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| 摘 要： | 原发性肝癌是我国最常见消化系统肿瘤之一，肝癌侵袭性强且复发率高，总体疗效往往不满意。肝X受体(liver X receptors,LXRs)是核受体超家族成员之一,最初发现其参与可调节胆固醇代谢及免疫应答。目前，细胞及分子生物学研究不断深入并取得新的进展,LXR在肝脏疾病尤其是肝癌的发生发展中作用明显,提示LXR是肝癌治疗中潜在的新治疗靶点，为肝癌治疗提供新的思路。
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| 关 键 词： | 肝X受体 肝癌 增殖 |
Progress in research on liver X receptor and liver cancer |
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| SHAO Cunhua,GUO Xingjun.Progress in research on liver X receptor and liver cancer[J].Journal of Modern Oncology,2021,0(4):700-703. |
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| Authors: | SHAO Cunhua GUO Xingjun |
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| Affiliation: | Department of Hepatobiliary Surgery,Dongying People's Hospital,Shandong Dongying 257091,China. |
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| Abstract: | Primary hepatocellular carcinoma(PHC)is one of the most common digestive system tumors in China.It is highly invasive and has a high recurrence rate.The overall curative effect is often unsatisfactory.Liver X receptors(LXRs)are members of the nuclear receptor superfamily.It was first found that LXRs are involved in regulating cholesterol metabolism and immune response.At present,cell and molecular biology research continues to deepen and make new progress.LXR plays an important role in the development of liver diseases,especially liver cancer,suggesting that LXR is a potential new therapeutic target in the treatment of liver cancer,providing new ideas for the treatment of liver cancer. |
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| Keywords: | liver X receptor liver cancer proliferation |
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