Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression |
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| Authors: | Brandy M Heckman-Stoddard Tracy Vargo-Gogola Peter R McHenry Vivian Jiang Matthew P Herrick Susan G Hilsenbeck Jeffrey Settleman Jeffrey M Rosen |
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| Affiliation: | (1) Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, 77030 Houston, TX, USA;(2) Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, 6120 Executive Boulevard, 20852 Bethesda, MD, USA;(3) Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 1234 Notre Dame Avenue, 46617 South Bend, IN, USA;(4) Lester and Sue Smith Breast Center and Department of Medicine, Baylor College of Medicine, One Baylor Plaza, 77030 Houston, TX, USA;(5) Massachusetts General Hospital Cancer Center and Harvard Medical School, 13th Street, 02129 Charlestown, MA, USA |
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| Abstract: | Introduction Rho signaling regulates key cellular processes including proliferation, survival, and migration, and it has been implicated in the development of many types of cancer including breast cancer. P190B Rho GTPase activating protein (RhoGAP) functions as a major inhibitor of the Rho GTPases. P190B is required for mammary gland morphogenesis, and overexpression of p190B in the mammary gland induces hyperplastic lesions. Hence, we hypothesized that p190B may play a pivotal role in mammary tumorigenesis. |
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