MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F1 MICE |
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| Authors: | Susumu Sugai Rao Pillarisetty Norman Talal |
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| Affiliation: | From the Section of Clinical Immunology and Arthritis, Veterans Administration Hospital and the University of California San Francisco, San Francisco, California 94121 |
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| Abstract: | ![]()
Serum monoclonal macroglobulins were detected in over 30% of NZB/NZW F1 mice greater than 11 mo of age. The monoclonal nature of the IgM was shown by restricted electrophoretic mobility, characteristic appearance on immunoelectrophoresis, restriction to a single light chain type, and ability to induce anti-idiotypic antisera. The monoclonal macroglobulins were separated from antibodies to DNA and RNA that migrated in the 7S region of sucrose gradients. Enlarged lymph nodes were often present in mice with monoclonal IgM, and a transplantable IgM-producing lymphoid tumor was established from the spleen of one animal. |
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