| 非霍奇金淋巴瘤患者外周血CD_4~+CD_(25)~(high)CD_(127)~(low)调节性T细胞检测的临床意义 |
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| 引用本文： | 赵志强,张巧花,苏文,侯淑玲,贺建霞.非霍奇金淋巴瘤患者外周血CD_4~+CD_(25)~(high)CD_(127)~(low)调节性T细胞检测的临床意义[J].白血病．淋巴瘤,2010,19(3):172-174,190. |
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| 作者姓名： | 赵志强 张巧花 苏文 侯淑玲 贺建霞 |
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| 作者单位： | 030001,太原,山西医科大学研究院;山西省肿瘤医院血液科;山西省肿瘤医院血液科;山西省肿瘤研究所免疫室 |
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| 摘 要： | 目的 观察非霍奇金淋巴瘤（NHL）患者外周血CD4^＋CD25^highCD127^low调节性T细胞（Treg细胞）亚群水平的变化,初步探讨其临床意义.方法 采用流式细胞术检测65例NHL患者及29名健康人外周血中Treg细胞,并进行统计分析.结果 在65例NHL患者的外周血中Treg细胞的比例为（6.72±1.38）%,高于健康对照组（5.65±0.68）%（P〈0.05）;Treg细胞在健康对照组为（5.65±0.68）%,NHL患者Ⅰ～Ⅱ期为（6.08±1.18）%,Ⅲ～Ⅳ期为（6.95±0.85）%,差异有统计学意义（P〈0.05）;Treg细胞在健康对照组为（5.65±0.68）%,弥漫大B细胞淋巴瘤为（5.83±0.95）%,其他亚型淋巴瘤为（7.83±1.76）%,差异有统计学意义（P〈0.05）;Treg细胞在乳酸脱氧酶（LDH）正常患者组为（6.97±1.20）%,增高患者组为（6.54±1.02）%,LDH不同水平与健康对照间差异无统计学意义（P〉0.05）.结论 Treg细胞为免疫抑制细胞,可由肿瘤诱导产生,肿瘤患者外周血中Treg细胞高于健康对照组,且随着患者临床分期的增加,Treg细胞比值升高,Treg细胞比值可以作为临床评估瘤负荷的指标.
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| 关 键 词： | 淋巴瘤 非霍奇金 T淋巴细胞 调节性 流式细胞术 |
Clinical significance of detection of CD_4~+CD_(25)~(high)CD_(127)~(low) regulatory T cells in peripheral blood of NHL patients |
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| ZHAO Zhi-qiang,ZHANG Qiao-hua,SU Wen,HOU Shu-ling,HE Jian-xia.Clinical significance of detection of CD_4~+CD_(25)~(high)CD_(127)~(low) regulatory T cells in peripheral blood of NHL patients[J].Journal of Leukemia & Lymphoma,2010,19(3):172-174,190. |
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| Authors: | ZHAO Zhi-qiang ZHANG Qiao-hua SU Wen HOU Shu-ling HE Jian-xia |
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| Affiliation: | . (Department of Graduate, Shanxi Medical University, Taiyuan 030001, China) |
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| Abstract: | Objective To investigate the change of CD_4~+CD_(25)~(high)CD_(127)~(low)> regulatory T cells (Trcg cells) sub-group level in peripheral blood of non-Hodgkin lymphama (NHL) patients, and to explore its clinical significance. Methods Treg cells levels in peripheral blood of lymphoma patients and normal were detected by flow cytometry, followed by statistical analysis. Results In the 65 cases of NHL patients, Treg cells in peripheral blood were (6.72±1.38) %, higher than that in the normal control group (5.65±0.68) % (P <0.05). Percentage of Treg cells are significantly different between clinical stages and normal: P <0.05, normal control group (5.65±0.88) %, Ⅰ -Ⅱ period (6.08±1.18) %, Ⅲ-Ⅳ period (6.95±0.85) %]. The percentage of Treg cells are also different among pathological types of patients and normal P <0.05, normal control group (5.65± 0.68) %. The percentage of Treg diffuse large B-cell lymphoma (5.83±0.95) % and other subtypes of lymphoma (7.83±1.76) %]were observed. It is not sure that Treg cells percentage among patients with different levels of lactate dehydrogenase and normal are significantly different. P >0.05, normal control group (5.65±0.68) %, patients with normal LDH group (6.97±1.20) %, patients with lactate dehydrogenase (6.54±1.02) %]. Conclusion Treg cells induced by tumor and could inhibit the immune cells, Treg cells percentage in peripheral blood of tumor patients is higher than that the normal control group, and increased with the clinical staging, so the percentage of Treg cells may serve as a clinical indicator to evaluate tumor load. |
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| Keywords: | Lymphoma non-Hodgkin T-lymphocytes regulatory Flow cytometry |
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