Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis |
| |
| Authors: | Petraitis Vidmantas Petraitiene Ruta Lin Pengxin Calis Karim Kelaher Amy M Muray Heidi A Mya-San Christine Mickiene Diana Bacher John Walsh Thomas J |
| |
| Affiliation: | Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Building 10, CRC, Rm. 1W-5740, 10 Center Dr., MSC 1100, Bethesda, Maryland 20892-1100, USA. |
| |
| Abstract: | The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
