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| 大疱性系统性红斑狼疮二例 | |
| 引用本文： | 陈显侠,余炳前,郑佳媛,牛桃香,李一凡,骆志成. 大疱性系统性红斑狼疮二例[J]. 中国麻风皮肤病杂志, 2020, 36(7): 415-416. DOI: 10.12144/zgmfskin202007415 |
| 作者姓名： | 陈显侠 余炳前 郑佳媛 牛桃香 李一凡 骆志成 |
| 作者单位： | 兰州大学第二医院皮肤科，甘肃兰州,730030 |
| 摘 要： | 2例患者均为女性，年龄分别为36岁和19岁。临床表现均为红斑基础上的水疱，尼氏征阴性。皮肤组织病理检查示：表皮角化不全，有中性粒细胞浸润，基底细胞液化变性。直接免疫荧光示IgA、lgG和C3呈线状或带状沉积于基底膜带。临床表现及实验室检查均符合系统性红斑狼疮的诊断标准。均给予糖皮质激素治疗后好转。 |
| 关 键 词： | 大疱性 系统性红斑狼疮 |
Bullous systemic lupus erythematosus: two cases report |
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| CHEN Xianxia,YU Bingqian,ZHENG Jiayuan,NIU Taoxiang,LI Yifan,LUO Zhicheng. Bullous systemic lupus erythematosus: two cases report[J]. China Journal of Leprosy and Skin Diseases, 2020, 36(7): 415-416. DOI: 10.12144/zgmfskin202007415 | |
| Authors: | CHEN Xianxia YU Bingqian ZHENG Jiayuan NIU Taoxiang LI Yifan LUO Zhicheng |
| Affiliation: | Department of Dermatology, The Second Hospital of Lanzhou University, Lanzhou 730030, China |
| Abstract: | The two patients were females, and the age was 36 and 19 years old respectively. Both patients presented with blisters on the erythema with negative Nikolsky sign. Histopathological examination of the skin showed epidermal parakeratosis, neutrophil infiltration, and liquefaction degeneration of basal cells. Direct immunofluorescence showed that IgA, lgG, and C3 were deposited linearly or zonally on the basement membrane zone. The diagnosis of bullous systemic lupus erythematosus was made according the clinical manifestations and laboratory tests. Both were treated with glucocorticoids and their lesions were improved. |
| Keywords: | bullous systemic lupus erythematosus |
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