Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils. |
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| Authors: | S Mariotto L Cuzzolin A Adami P Del Soldato H Suzuki G Benoni |
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| Affiliation: | Istituto di Chimica Biologica, Università di Verona, Italy. |
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| Abstract: | ![]()
A well-known nitric oxide (NO)-releasing compound, sodium nitroprusside (SNP), decreases in a dose-dependent manner NO synthase (NOS) activity induced in rat neutrophils by treatment with lipopolysaccharide (LPS). This inhibitory action of SNP seems not to be due to its direct effect on the enzyme activity. The strong nitrosonium ion (NO+) character of SNP could be responsible for its inhibition of NOS induction in neutrophils. |
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