| 干细胞源性细胞外囊泡经RANKL/RANK/OPG通路促进牙槽骨成骨的研究进展 |
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| 引用本文： | 黄霞,魏津钿,苏琦,周志迎,项琪.干细胞源性细胞外囊泡经RANKL/RANK/OPG通路促进牙槽骨成骨的研究进展[J].中国现代医学杂志,2023(20):60-64. |
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| 作者姓名： | 黄霞 魏津钿 苏琦 周志迎 项琪 |
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| 作者单位： | 1.暨南大学 口腔医学院， 广东 广州 510632;2.暨南大学第一附属医院 口腔科， 广东 广州 510630;3.暨南大学 生物医药研究院， 广东 广州 510632 |
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| 基金项目： | 国家重点研发计划（No：2022YFC2403100）；广东省重点领域研发计划（No：2022B1111080007）；广州市重点研发计划（No：202103030003） |
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| 摘 要： | 干细胞源性细胞外囊泡（SC-EVs）是由干细胞分泌的脂质囊泡，在组织再生医学中具有广泛的应用前景。目前已发现SC-EVs能够促进牙槽骨成骨再生，但成骨机制尚不明确。RANKL/RANK/OPG信号通路是调节骨代谢的重要通路，因此该文就RANKL/RANK/OPG信号通路在促进牙槽骨成骨的作用作一综述，为研究SC-EVs的成骨机制提供参考。
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| 关 键 词： | 干细胞 细胞外囊泡 牙槽骨 成骨 |
| 收稿时间： | 2023/3/7 0:00:00 |
Research advances in the role of stem cell-derived extracellular vesicles in promoting osteogenesis of the alveolar bone through the RANKL/RANK/OPG pathway |
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| Huang Xi,Wei Jin-tian,Su Qi,Zhou Zhi-ying,Xiang Qi.Research advances in the role of stem cell-derived extracellular vesicles in promoting osteogenesis of the alveolar bone through the RANKL/RANK/OPG pathway[J].China Journal of Modern Medicine,2023(20):60-64. |
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| Authors: | Huang Xi Wei Jin-tian Su Qi Zhou Zhi-ying Xiang Qi |
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| Abstract: | Stem cell-derived extracellular vesicles (SC-EVs) are lipid vesicles secreted by stem cells, with prospects for being extensively applied in the field of tissue engineering and regenerative medicine. At present, it has been found that SC-EVs can promote the regeneration of the alveolar bone, but the mechanism of osteogenesis is still unclear. The RANKL/RANK/OPG signaling pathway is essential for regulating the bone metabolism. Therefore, this review summarizes the role of the RANKL/RANK/OPG signaling pathway in promoting osteogenesis of the alveolar bone, providing an insight for investigating the mechanism of osteogenesis mediated by SC-EVs. |
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| Keywords: | stem cell extracellular vesicles alveolar bone osteogenesis |
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