| 急诊溶栓治疗STEMI的疗效及对患者心功能、心肌细胞坏死指标和炎性指标的影响 |
| |
| 引用本文： | 谢华磊,冯泽瑞,吕振环,刘敏,王甲莉,潘凌云.急诊溶栓治疗STEMI的疗效及对患者心功能、心肌细胞坏死指标和炎性指标的影响[J].中华全科医学,2019,17(1):63-65. |
| |
| 作者姓名： | 谢华磊 冯泽瑞 吕振环 刘敏 王甲莉 潘凌云 |
| |
| 作者单位： | 泰山医学院附属医院 聊城市第二人民医院急诊科, 山东 聊城 252600 |
| |
| 基金项目： | 山东省科学技术厅重点研发计划项目(2018GSF118003) |
| |
| 摘 要： | 目的 研究急诊溶栓治疗急性ST段抬高型心肌梗死(ST-elevation mycocardial infarction,STEMI)患者的疗效以及对患者心脏功能指标、心肌细胞坏死标记物指标和炎性指标的影响。 方法 选取2017年6月—2018年6月聊城市第二人民医院急诊入院的STEMI患者70例,对所有患者进行溶栓治疗,并根据溶栓时间不同分为0~1h溶栓组、1~3 h溶栓组、3~6 h溶栓组。检测并比较溶栓后的心脏功能指标、心肌细胞坏死标记物指标和炎性指标。 结果 0~1 h溶栓组患者的舒张早期最大峰值速度(E峰)、E/A比值、左室射血分数(LVEF)、左室舒张末容积(LVEDD)均高于1~3 h溶栓组和3~6 h溶栓组,差异均有统计学意义(均P<0.05),心脏功能指标与溶栓时间呈负相关。0~1 h溶栓组患者的肌钙蛋白T (c Tn T)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)水平均低于1~3 h溶栓组和3~6 h溶栓组,差异均有统计学意义(均P<0.01),心肌细胞坏死标记物相关指标与溶栓时间呈正相关。0~1 h溶栓组C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)水平均低于1~3h溶栓组和3~6 h溶栓组,差异均有统计学意义(均P<0.01),炎性指标与溶栓时间呈正相关。 结论 急诊溶栓的时间越短,患者溶栓后的心脏功能越好,心肌细胞坏死越少、炎症反应水平越低。
|
| 关 键 词： | 心肌梗死 ST段抬高 溶栓治疗 心功能 炎症因子 |
| 收稿时间： | 2018-07-19 |
Effect of thrombolytic therapy on STEMI in patients with acute myocardial infarction and its effect on cardiac function,myocardial necrosis and inflammatory index |
| |
| Affiliation: | Department of Emergency, the Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, China |
| |
| Abstract: | Objective To study the effect of thrombolytic therapy on ACS in patients with acute myocardial infarction and its effect on cardiac function, myocardial necrosis and inflammatory index. Methods Seventy patients with acute myocardial infarction from December 2017 to June 2018 in our hospital emergency department admissions ST elevation cases, thrombolytic therapy for patients, and according to the time of thrombolysis were divided into thrombolysis group 0-1 h, 1-3 h, 3-6 h thrombolysis group, thrombolysis group. The cardiac function, myocardial necrosis and inflammatory index were measured and compared. Results E peak, E/A ratio, LVEF, LVEDD were higher in the 0-1 h thrombolysis group than in the thrombolysis group and the thrombolytic group of 3-6 h in the group from 1 to 3 h, the difference was statistically significant (P < 0.05), and there was a negative correlation between cardiac function and thrombolysis time.The c Tn T, LDH, CK-MB levels of 0 to 1 h thrombolysis group were lower than those of thrombolysis group and thrombolysis group from 1 to 3 h in the group from 3 to 6 h, the difference was statistically significant (P < 0.01). There were positively correlated between the indexes of myocardial cell necrosis and thrombolysis time. The inflammatory factors CRP, TNF, IL-1 levels in 0-1 h thrombolysis group were lower than those in the group of thrombolytic therapy from 1 to 3 h and from 3 to 6 h, the difference was statistically significant (P < 0.01). Inflammatory index was positively correlated with thrombolysis time. Conclusion The shorter the time of thrombolytic therapy, the better the cardiac function of patients after thrombolysis. The less necrosis of myocardial cells, the lower the level of inflammatory response. |
| |
| Keywords: | |
|
| 点击此处可从《中华全科医学》浏览原始摘要信息 |
|
点击此处可从《中华全科医学》下载全文 |
|
