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| 影像组学预测甲状腺乳头状癌中央区淋巴结转移 | |
| 引用本文： | 王伟镇,李颖嘉. 影像组学预测甲状腺乳头状癌中央区淋巴结转移[J]. 南方医科大学学报, 2019, 39(9): 1094. DOI: 10.12122/j.issn.1673-4254.2019.09.15 |
| 作者姓名： | 王伟镇 李颖嘉 |
| 作者单位： | 南方医科大学南方医院超声医学科,广东 广州,510515;南方医科大学南方医院超声医学科,广东 广州,510515 |
| 摘 要： | 目的探讨影像组学方法提取甲状腺乳头状癌（PTC）的纹理特征以预判颈部中央区淋巴结转移的可能性。方法前瞻性收集本院接受甲状腺细针穿刺活检证实为PTC的189例患者，常规超声检查有无中央区淋巴结转移；然后基于其PTC的超声横切面、纵切面及双切面的纹理特征，利用随机森林方法对纹理特征进行筛选并建立预测模型，预测颈部中央区淋巴结是否发生转移，并以最终手术病理结果为金标准进行比对。结果189例患者中，术前甲状腺超声检查诊断颈部中央区淋巴结转移的准确率为35%，灵敏度为28.6%，特异度为55%。影像组学分析PTC的超声横切面/纵切面/双切面预测颈部中央区淋巴结转移的准确率为66.06%／68.12%/77.69%，灵敏度为53%/46%/40%，特异度为52%/53%/51%。结论结合PTC的超声横及纵双切面纹理特征，影像组学方法预测颈部中央区淋巴结转移的准确性较单切面高，且远高于常规超声检查的准确率。 |
| 关 键 词： | 甲状腺乳头状癌 中央区淋巴结转移 影像组学 |
Radiomics for prediction of central lymph node metastasis in the neck in patients withthyroid papillary carcinoma |
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| Abstract: | Objective To explore the feasibility of radiomics for predicting lymph node metastasis in the central region of theneck in patients with thyroid papillary carcinoma (PTC). Methods A total of 189 patients with PTC confirmed by thyroid fineneedle aspiration biopsy were prospectively enrolled in this study. The cross-sectional and longitudinal ultrasound images andthe images of both sections were analyzed for predicting central lymph node metastasis using a radiomics approach withpathological results as the gold standard. Results In the 189 patients, the accuracy, sensitivity and specificity of preoperativethyroid ultrasonography for diagnosis of central lymph node metastasis was 69.39%, 64% and 73%, respectively. Based on theultrasound images of the cross-sections, longitudinal sections and both sections, the accuracy, sensitivity and specificityof radiomics for predicting central lymph node metastasis was 66.06%/68.12%/77.69% , 53%/46%/40% , and 52%/53%/51% ,respectively. Conclusion Radiomics with combined analysis of the ultrasound images on the cross-section and longitudinalsection images achieves a higher accuracy for predicting central lymph node metastasis than analysis a single section, and itsdiagnostic accuracy is much higher than that of conventional ultrasound examination. |
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