| 自体骨髓移植联合MHC单倍体相合淋巴细胞治疗急性髓性白血病的临床疗效 |
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| 引用本文： | 石瑞平,韩婷婷,郭树霞.自体骨髓移植联合MHC单倍体相合淋巴细胞治疗急性髓性白血病的临床疗效[J].现代肿瘤医学,2019,0(10):1812-1815. |
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| 作者姓名： | 石瑞平 韩婷婷 郭树霞 |
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| 作者单位： | 1.郑州人民医院血液内科,河南 郑州 450000;2.北京大学人民医院血液科,北京 100000 |
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| 基金项目： | 河南省医学科技攻关计划项目（编号:201203154） |
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| 摘 要： | 目的:自体骨髓移植联合MHC单倍体相合淋巴细胞治疗急性髓性白血病的治疗效果和安全性。方法:以40例急性髓性白血病患者作为研究对象，随机分为两组各20例，研究组患者使用自体骨髓移植联合MHC单倍体相合淋巴细胞进行治疗，对照组单用自体骨髓移植进行治疗。结果:两组患者的造血系统都得到重建，重建时间以及并发症的发生均没有显著差异。而研究组患者复发率显著降低，且复发时间明显地长于对照组患者。研究组患者3年累积无病生存率明显地高于对照组患者，且差异具有统计学意义。结论:自体骨髓移植联合MHC单倍体相合淋巴细胞治疗能够有效控制急性髓性白血病病情，降低其复发，延长患者生存期。
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| 关 键 词： | 自体骨髓移植 MHC单倍体相合免疫细胞 白血病 复发 生存期 |
Clinical efficacy of autologous bone marrow transplantation combined with MHC haploidentical immune cells in the treatment of leukemia |
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| Shi Ruiping,Han Tingting,Guo Shuxia.Clinical efficacy of autologous bone marrow transplantation combined with MHC haploidentical immune cells in the treatment of leukemia[J].Journal of Modern Oncology,2019,0(10):1812-1815. |
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| Authors: | Shi Ruiping Han Tingting Guo Shuxia |
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| Affiliation: | 1.Hematology Department,Zhengzhou People's Hospital，Henan Zhengzhou 450000，China;2.Hematology Department,Beijing University People's Hospital，Beijing 100000,China. |
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| Abstract: | Objective:To investigate the clinical effect and safety of autologous bone marrow transplantation combined with MHC haploidentical immune cells in the treatment of leukemia.Methods:40 patients with leukemia were randomly divided into two groups,20 patients in each group.The patients in the study group were treated with autologous bone marrow transplantation combined with MHC haploidentical immune cells,and the control group was treated with autologous bone marrow transplantation alone.Results:There was no significant difference between the two groups in the reconstitution of hematopoietic system,the time of reconstruction and the occurrence of complications.The recurrence rate of the study group was significantly decreased,and the recurrence time was significantly higher than that of the control group.The 3-year cumulative disease free survival rate of the study group was significantly higher than that of the control group,and the difference was statistically significant.Conclusion:Autologous bone marrow transplantation combined with MHC haploidentical immune cell therapy can effectively control leukemia,reduce the recurrence of leukemia,and prolong the survival time of patients. |
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| Keywords: | autologous bone marrow transplantation MHC haploidentical immune cells leukemia recurrence survival |
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