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| 青光眼视神经节细胞凋亡的作用机制研究进展 | |
| 引用本文： | 吴姗姗,田庆梅,高延娥,毕宏生. 青光眼视神经节细胞凋亡的作用机制研究进展[J]. 眼科新进展, 2019, 0(9): 882-885. DOI: 10.13389/j.cnki.rao.2019.0201 |
| 作者姓名： | 吴姗姗 田庆梅 高延娥 毕宏生 |
| 作者单位： | 250014 山东省济南市，山东中医药大学［吴姗姗（2017级硕士研究生），田庆梅（2017级博士研究生）］；250002 山东省济南市，山东省中西医结合眼病防治重点实验室；山东省高校中西医结合眼病防治技术（强化） 重点实验室；山东中医药大学眼科研究所（高延娥，毕宏生）；250002 山东省济南市，山东中医药大学附属眼科医院（毕宏生） |
| 基金项目： | 国家自然科学基金(编号:81503620、81674032);山东省自然科学基金(编号:ZR2016HP27、ZR2017LH042);山东中医药科技发展计划(编号:2015-145)~~ |
| 摘 要： | 青光眼是一组以视神经退行性病变、视野缺损和视力下降为特征的不可逆性致盲性眼病。青光眼的发生主要涉及视网膜神经节细胞(retinal ganglion cells,RGC)的变性、凋亡、进行性丧失。目前,青光眼RGC凋亡的具体机制尚未明确,其中涉及多种凋亡途径和凋亡相关因子,包括死亡受体途径、线粒体途径、内质网途径等凋亡机制及caspases等凋亡因子参与。本文就RGC几种常见凋亡途径及凋亡相关因素做一简要综述,对青光眼的靶向治疗提供一定的理论依据,进而为临床治疗青光眼提供可靠的分子依据。 |
| 关 键 词： | 青光眼 视网膜神经节细胞 凋亡 |
Advances in research on the mechanism of apoptosis of glaucoma optic ganglion cells |
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| WU Shan-Shan,TIAN Qing-Mei,GAO Yan-E,BI Hong-Sheng. Advances in research on the mechanism of apoptosis of glaucoma optic ganglion cells[J]. Recent Advances in Ophthalmology, 2019, 0(9): 882-885. DOI: 10.13389/j.cnki.rao.2019.0201 | |
| Authors: | WU Shan-Shan TIAN Qing-Mei GAO Yan-E BI Hong-Sheng |
| Affiliation: | Shandong University of Traditional Chinese Medicine；Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases；Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention an Therapy of Ocular Disease in University of Shandong；Eye Institute of Shandong University of Traditional Chinese Medicine；Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine |
| Abstract: | Glaucoma is an irreversible blinding eye disease characterized by optic nerve degeneration,visual field defect and vision loss.The progress of glaucoma mainly involves degeneration,apoptosis and progressive loss of retinal ganglion cells (RGC).Currently,glaucoma is related to many apoptosis pathways and apoptosis-related factors including death receptor pathway,mitochondrial pathway,endoplasmic reticulum pathway,and apoptotic factors such as apoptosis-related enzyme caspase,nevertheless,the underlying mechanism remains undefined.In this paper,a brief review of several common apoptotic pathways and apoptosis-related factors of RGC is sumarried,providing a new insight in theoretical basis for the targeted treatment of glaucoma and reliable molecular basis for clinical treatment of glaucoma. |
| Keywords: | glaucoma retinal ganglion cells apoptosis |
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