| PDX模型在恶性肿瘤中应用的研究进展 |
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| 引用本文： | 闫克敏,孙佳,王娇娇,聂勇战,肖海娟,' target='_blank'>.PDX模型在恶性肿瘤中应用的研究进展[J].现代肿瘤医学,2019,0(9):1629-1634. |
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| 作者姓名： | 闫克敏 孙佳 王娇娇 聂勇战 肖海娟 ' target='_blank'> |
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| 作者单位： | 1.陕西中医药大学，陕西 咸阳 712046；2.空军军医大学西京消化病医院，陕西 西安 710032；3.陕西中医药大学附属医院肿瘤科，陕西 咸阳 712000 |
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| 基金项目： | 中国博士后科学基金（编号:2017M613351）；陕西省自然科学基金（编号:2015JQ8288，2018JQ8014） |
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| 摘 要： | 人源异种移植模型（patient-derived xenograft，PDX）在反应肿瘤异质性及保留原代肿瘤生物学特性方面具有独特优势，在肺癌、胃癌、肝癌、食管癌、结直肠癌和胰腺癌等研究中应用广泛，涉及药物的疗效评价、化疗耐药研究及预测临床预后等诸多领域。
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| 关 键 词： | PDX模型 恶性肿瘤 研究进展 |
Research progress of PDX model in application of malignant tumors |
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| Yan Kemin,Sun Jia,Wang Jiaojiao,Nie Yongzhan,Xiao Haijuan,' target='_blank'>.Research progress of PDX model in application of malignant tumors[J].Journal of Modern Oncology,2019,0(9):1629-1634. |
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| Authors: | Yan Kemin Sun Jia Wang Jiaojiao Nie Yongzhan Xiao Haijuan ' target='_blank'> |
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| Affiliation: | 1.Shaanxi University of Chinese Medicine，Shaanxi Xianyang 712046，China；2.Xijing Hospital of Digestive Disease，Air Force Medical University，Shaanxi Xi'an 710032，China；3.Department of Oncology，Hospital Affliated to Shaanxi University of Chinese Medicine，Shaanxi Xianyang 712000，China. |
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| Abstract: | Patient-derived xenograft(PDX) model has the unique advantages in response to tumor heterogeneity and preserving the biological characteristics of primary tumors.The PDX model is widely used in lung cancer，gastric cancer，liver cancer，esophageal cancer，colorectal cancer，and pancreatic cancer.It involves the evaluation of drug efficacy，chemotherapy resistance，and prediction of clinical prognosis. |
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| Keywords: | PDX model malignant tumor research progress |
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