Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis |
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| Authors: | Abolghasem Hadinia1Amir Hossein Doustimotlagh2 3Hamed Reza Goodarzi1Arash Arya4Mojtaba Jafarinia1 |
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| Affiliation: | 1Department of Genetic, Marvdasht branch, Islamic Azad University, Marvdasht, Iran2Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran3Department of Clinical Biochemistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran4Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran |
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| Abstract: | Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy volunteers. The plasma level of IL-1b, IL-6, and TNF-a were determined by ELISA, and biochemical parameters were measured using colorimetric methods. Results: IL-1b and IL-6 levels were significantly higher in patients with NASH compared with NAFL and control group. However, TNF-a levels had no significant variations in NAFL and NASH patients compared to the control group (p=0.903 and p=0.960, respectively). Conclusion: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH. |
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| Keywords: | Interleukin-1β Interleukin-6 Non-Alcoholic Fatty Liver Non-Alcoholic Steatohepatitis Tumor Necrosis Factor-α |
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