| 阴茎上皮样肉瘤1例报告并文献复习 |
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| 引用本文： | 付梓峰1,梁国标1,梁天才1,杜 洋1,李 浩1,杜 江1,宋先初1,陈安健1,杨晓荣2. 阴茎上皮样肉瘤1例报告并文献复习[J]. 现代肿瘤医学, 2019, 0(11): 1937-1940. DOI: 10.3969/j.issn.1672-4992.2019.11.021 |
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| 作者姓名： | 付梓峰1 梁国标1 梁天才1 杜 洋1 李 浩1 杜 江1 宋先初1 陈安健1 杨晓荣2 |
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| 作者单位： | 1.遵义医科大学附属医院泌尿外科；2.病理科，贵州 遵义 563000 |
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| 基金项目： | 贵州省优秀青年科技人才培养对象专项资金项目［编号:黔科合人字（2015）31号］ |
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| 摘 要： | 目的:探讨阴茎上皮样肉瘤的临床、病理特征、诊断、治疗方法及预后。方法:回顾性分析1例阴茎上皮样肉瘤患者的临床资料及诊治流程并结合文献复习。结果:69岁男性患者，因发现阴茎根部进行性增大包块3月入院就诊。下腹部CT示阴茎根部大小5.9 cm×5.6 cm×6.5 cm软组织肿块，倾向恶性肿瘤，肉瘤可能性大。行阴茎根部肿瘤切除术，术后病理诊断:镜下见肿瘤细胞呈圆形或卵圆形，染色深浅不一，部分呈空泡状，核仁明显。免疫组化染色结果:CK广谱（-），vimentin（部分+），EMA(大部分+)，CD34(血管+)，CD31(血管+)，CD99(+)，S-100(-)，Bcl-2(-)，HMB45(-)，SMA(-)，AFP(-)。术后患者恢复可出院，未行进一步治疗。术后7月患者发现左侧腹股沟出现进行性增大包块，术后10月患者复查盆腔CT示阴茎根部上份盆壁、左侧睾丸及左侧腹股沟区见多发软组织肿块，最大者位于左侧腹股沟区，大小约7.6 cm×6.8 cm，考虑局部复发并左侧睾丸、腹股沟转移，患者自行放弃行进一步治疗，最后随访日期为2018年1月。结论:阴茎上皮样肉瘤是一种罕见的阴茎间质恶性肿瘤，确诊依赖于病理学及特异性免疫组化染色结果，手术切除是其主要治疗方法，术后是否行放化疗治疗尚存争议，其易局部复发及区域淋巴结转移，总体预后较差。
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| 关 键 词： | 上皮样肉瘤 阴茎肿瘤 治疗 预后 |
Penile epithelioid sarcoma:A case report and review of literature |
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| Fu Zifeng1,Liang Guobiao1,Liang Tiancai1,Du Yang1,Li Hao1,Du Jiang1,Song Xianchu1,Chen Anjian1,Yang Xiaorong2. Penile epithelioid sarcoma:A case report and review of literature[J]. Journal of Modern Oncology, 2019, 0(11): 1937-1940. DOI: 10.3969/j.issn.1672-4992.2019.11.021 |
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| Authors: | Fu Zifeng1 Liang Guobiao1 Liang Tiancai1 Du Yang1 Li Hao1 Du Jiang1 Song Xianchu1 Chen Anjian1 Yang Xiaorong2 |
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| Affiliation: | 1.Department of Urology；2.Department of Pathology，Affiliated Hospital of Zunyi Medical University，Guizhou Zunyi 563000，China. |
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| Abstract: | Objective:To investigate the clinical，pathological features，diagnosis，treatment and prognosis of penile epithelioid sarcoma.Methods:This is A retrospective analysis of a case of penile epithelioid sarcoma in clinical data and diagnosis and treatment process combined with literature review.Results:69-year-old male patient，due to the founding of the penis root progressive enlargement mass was admitted to the hospital for 3 months.The lower abdomen CT showed a soft tissue mass of 5.9 cm×5.6 cm×6.5 cm in the base of the penis，which tended to be a malignant tumor，and the possibility of sarcoma was large.Resection of penile root tumor and postoperative pathological diagnosis microscopically showed the tumor cells were round or oval，with different staining depths，some vacuoles，and obvious nucleoli.Immunohistochemical staining results showed CK broad spectrum (-)，vimentin(part+)，EMA(most +)，CD34(vessel+)，CD31(vessel+)，CD99(+)，S-100(-)，Bcl-2(-)，HMB45(-)，SMA(-)，AFP(-).The patient recovered after surgery and was discharged without further treatment.After 7 months，the patient found a progressive enlargement of the mass in the left groin.After 10 months，the patient underwent pelvic CT to show the upper pelvic wall of the penis，the left testis and the left groin area with multiple soft tissue masses.The largest one was left.The lateral groin area was about 7.6 cm×6.8 cm.Considering local recurrence and left testicular and groin metastasis，the patient gave up treatment for further treatment.The final follow-up date was January 2018.Conclusion:Penile epithelioid sarcoma is a rare malignant tumor of the penis.The diagnosis depends on the pathological and specific immunohistochemical staining results.Surgical resection is the main treatment.There is controversy whether radiotherapy and chemotherapywe received after operation.It is easy to local recurrence and regional lymph node metastasis，and the overall prognosis is poor. |
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| Keywords: | epithelioid sarcoma penile neoplasms treatment prognosis |
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