| 2013-2017年贵州省艾滋病患者HIV亚型分布 |
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| 引用本文： | 柳兴凤,李志坚,方星,张信辉,黄璐,王欢,肖智.2013-2017年贵州省艾滋病患者HIV亚型分布[J].中华疾病控制杂志,2019,23(12):1523-1526. |
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| 作者姓名： | 柳兴凤 李志坚 方星 张信辉 黄璐 王欢 肖智 |
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| 作者单位： | 1.563000 遵义, 遵义医科大学贵州省普通高等学校脑科学特色重点实验室 |
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| 基金项目： | 贵州省教育厅项目qian jiao he KY[2015]331贵州省卫健委项目gzwjkj2018-2-001 |
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| 摘 要： | 目的 调查贵州省接受抗逆转录病毒治疗（antiretroviral therapy，ART）的人类免疫缺陷病毒/艾滋病（human immunodeficiency virus/acquired immune deficiency syndrome，HIV/AIDS）患者的HIV亚型分布特征，为艾滋病防治提供参考。 方法 采用方便抽样策略，收集贵州省2013-2017年间8 583份抗病毒治疗半年以上的在治艾滋病患者血浆，采用面对面问卷调查、HIV检测等横断面调查。 结果 其中有1 511例HIV病毒抑制失败（病毒载量，viral load，VL>1 000 copies/ml），成功对1 410例（93.31%）HIV抑制失败患者的HIV pol基因进行基因分型。结果显示，51.42%为CRF01_AE基因型，26.67%为CRF07_BC基因型，16.1%为CRF08_BC基因型。 结论 通过对贵州省近年来HIV流行亚型和主要传播途径的变化分析，提示HIV基因突变引起亚型的改变应先于HIV主要传播途径的改变，及时监测HIV亚型变化可作为防治艾滋病的主要依据之一。
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| 关 键 词： | 艾滋病 抗逆转录病毒治疗 人类免疫缺陷病毒 亚型分布 |
| 收稿时间： | 2019-04-09 |
Distribution of HIV subtypes in HIV/AIDS patients in Guizhou from 2013 to 2017 |
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| Affiliation: | 1.Key Laboratory of Brain Science, Guizhou Institution of Higher Education, Zunyi Medical University, Zunyi 563000, China2.Guizhou Center of Disease Prevention and Control, Guiyang 550000, China3.Key Laboratory of infectious disease & Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi 563000, China |
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| Abstract: | Objective To investigate the molecular characteristics of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients receiving antiretroviral therapy (ART) in Guizhou Province. Methods Using a convenience sampling strategy, 8 583 samples were collected in Guizhou and an investigation was conducted including face-to-face questionnaire interview and HIV testing. Results 1 511 cases failed in HIV suppression (viral load, VL>1 000 copies/ml). 1 410 cases (93.31%) were successfully genotyped with HIV pol gene, among which 51.42% were genotyped as CRF01_AE, 26.67% as CRF07_BC and 16.1% as CRF08_BC. Conclusion The subtype changes caused by HIV gene mutation should precede the changes of main transmission routes of HIV through the analysis in recent years. Timely monitoring the changes of HIV subtypes can be one of the main bases for the prevention and control of AIDS. |
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