| IgD型多发性骨髓瘤的诊治现状及展望 |
| |
| 引用本文： | 宋变变,廖爱军.IgD型多发性骨髓瘤的诊治现状及展望[J].现代肿瘤医学,2019,0(14):2604-2607. |
| |
| 作者姓名： | 宋变变 廖爱军 |
| |
| 作者单位： | 中国医科大学附属盛京医院血液内科，辽宁 沈阳 110004 |
| |
| 基金项目： | National Natural Science Foundation of China(No.81272629）；国家自然科学基金（编号:81272629）；沈阳市科技计划项目（编号:17-231-1-58） |
| |
| 摘 要： | IgD型多发性骨髓瘤(IgD multiple myeloma,IgD MM)是多发性骨髓瘤(multiple myeloma,MM)中一种罕见类型,以年轻男性患者居多。主要表现为高钙血症、肾衰竭、贫血、骨损害、髓外浸润和系统性淀粉样变性等,具有侵袭性高,预后较差的特点。近年来,随着免疫调节剂(沙利度胺、来那度胺)、蛋白酶抑制剂(硼替佐米)等药物以及自体造血干细胞移植(autologous stem cell transplantation,ASCT)的应用,IgD型MM的预后得到明显改善。新一代蛋白酶体抑制剂、CD38单克隆抗体、组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitor,HDACI)、新型免疫治疗技术等治疗方法也为IgD型MM的治疗提供了新的方向。目前关于IgD型MM的相关报道较少,本文就IgD型MM的临床特点、诊断、治疗、预后及新药研究现状进行如下综述。
|
| 关 键 词： | IGD型多发性骨髓瘤 诊断 治疗 |
Current status and prospect of diagnosis and treatment of IgD multiple myeloma |
| |
| Song Bianbian,Liao Aijun.Current status and prospect of diagnosis and treatment of IgD multiple myeloma[J].Journal of Modern Oncology,2019,0(14):2604-2607. |
| |
| Authors: | Song Bianbian Liao Aijun |
| |
| Affiliation: | Department of Hematology,Shengjing Hospital of China Medical University，Liaoning Shenyang 110004,China. |
| |
| Abstract: | IgD multiple myeloma (IgD MM) is a rare type of multiple myeloma (MM),and the majority of patients are young men.It is characterized as hypercalcemia,renal insufficiency,anemia,bone disease,extramedullary infiltration and amyloidosis.Besides,IgD MM is invasive and has poor prognosis.In recent years,the prognosis of IgD MM has been significantly improved with the application of immunomodulators (thalidomide,lenalidomide),proteasome inhibitors (bortezomib) and other drugs,as well as autologous stem cell transplantation (ASCT).The new generation of proteasome inhibitors,CD38 monoclonal antibodies,histone deacetylase inhibitor (HDACI) and new immunotherapy technologies also provide new directions for the treatment of IgD MM.Due to the few reports on the disease of IgD MM,this article is going to review the IgD MM on clinical characteristics,diagnosis,treatment,prognosis and research status of new drugs. |
| |
| Keywords: | IgD multiple myeloma diagnosis treatment |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载全文 |
|
