| 卡维地洛对糖尿病心肌病病人代谢、炎症反应及心功能的影响 |
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| 引用本文： | 肖日军,胡兰,谷铁波,周晓峰. 卡维地洛对糖尿病心肌病病人代谢、炎症反应及心功能的影响[J]. 蚌埠医学院学报, 2021, 46(1): 36-38, 43. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.010 |
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| 作者姓名： | 肖日军 胡兰 谷铁波 周晓峰 |
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| 作者单位： | 1.湖南省湘潭市第一人民医院 内分泌科, 4111012.湖南省湘潭市第一人民医院 药学部, 411101 |
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| 基金项目： | 湖南省湘潭市医学会科研项目 |
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| 摘 要： | ![]()
目的探讨卡维地洛对糖尿病心肌病（DCM）病人代谢、炎症反应及心功能的影响。方法按照随机数字法将180例DCM病人分为对照组88例和观察组92例。对照组病人给予常规治疗，观察组病人在常规治疗的基础上加用卡维地洛（3.125~6.25 mg/d）。治疗12周后，比较2组生化指标[总胆固醇（TC）、三酰甘油（TG）、空腹血糖（FBG）]、炎症指标[超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）]、心功能指标[左室舒张末期内径（LVEDd）、左室收缩末期前后径（LVEDs）、左室射血分数（LVEF）、氨基末端脑钠肽前体（NT-pro-BNP）、6min步行距离]以及不良反应发生情况。结果治疗后，2组病人的hs-CRP、TNF-α水平均明显下降（P < 0.01），且观察组的hs-CRP、TNF-α水平明显低于对照组（P < 0.01）。治疗后，2组LVEDd、LVEDs及NT-pro BNP水平均明显下降（P < 0.01），LVEF与6min步行距离均明显提高（P < 0.01）；且观察组的LVEDd、LVEDs及NT-pro BNP水平明显低于对照组（P < 0.01），LVEF与6min步行距离明显高于对照组（P < 0.01）。2组均未发生严重不良反应导致病例退出研究。对照组发生干咳2例、头痛头晕3例，观察组发生头痛头晕5例、恶心1例，2组不良反应发生情况差异无统计学意义（P>0.05）。结论卡维地洛能够显著改善对DCM病人的炎症状态及心功能，对血脂及血糖无明显影响。
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| 关 键 词： | 糖尿病心肌病 心功能 炎症反应 卡维地洛 |
| 收稿时间： | 2018-05-30 |
Impact of carvedilol on the metabolism,inflammatory response and cardiac function of patients with diabetic cardiomyopathy |
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| XIAO Ri-jun,HU Lan,GU Tie-bo,ZHOU Xiao-feng. Impact of carvedilol on the metabolism,inflammatory response and cardiac function of patients with diabetic cardiomyopathy[J]. Journal of Bengbu Medical College, 2021, 46(1): 36-38, 43. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.010 |
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| Authors: | XIAO Ri-jun HU Lan GU Tie-bo ZHOU Xiao-feng |
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| Affiliation: | 1.Department of Endocrinology, The First People's Hospital of Xiangtan City, Xiangtan Hunan 411101, China2.Department of Pharmacy, The First People's Hospital of Xiangtan City, Xiangtan Hunan 411101, China |
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| Abstract: | ![]()
ObjectiveTo discuss the impacts of carvedilol on metabolism, inflammatory response and cardiac function of patients with diabetic cardiomyopathy(DCM).MethodsOne hundred and eighty DCM patients were divided into the control group(n=88)and observation group(n=92)according to random number method in our hospital.The control group were treated with conventional method, and the observation group were additionally treated with carvedilol(3.125~6.25 mg/d)based on conventional method.After 12 weeks of treatment, the biochemical indexes[including total cholesterol(TC), triglyceride(TG)and fasting blood-glucose(FBG)], inflammation markers[including high-sensitivity C-reactive protein(hs-CRP)and tumour necrosis factor-α(TNF-α)], heart function parameters[including left ventricular end diastolic diamete(LVEDd), left ventricular end-systolic diameter(LVEDs), left ventricular ejection fraction(LVEF), N-terminal pro-brain natriuretic peptid(NT-pro-BNP)and 6mmin walking distance] and adverse reaction were compared between two groups.ResultsAfter treatment, the levels of hs-CRP and TNF-αin two groups significantly decreased(P < 0.01), and the levels of hs-CRP and TNF-α in observation group were significantly lower than those in control group(P < 0.01).After treatment, the levels of LVEDd, LVEDs and NT-pro BNP significantly decreased(P < 0.01), and the LVEF level and 6min walking distance significantly increased in two groups(P < 0.01).After treatment, the levels of LVEDd, LVEDs and NT-pro BNP in observation group were significantly lower than those in control group(P < 0.01), and the LVEF level and 6min walking distance in observation group were significantly higher than those in control group(P < 0.01).No severe adverse reaction occurred in two groups.The dry cough in 2 cases and headache in 3 cases in control group, and dizziness and headache in 5 cases and dizziness and nausea in 1 case in observation group were found, and the difference of the incidence of adverse reactions between two groups was not statistically significant(P>0.05).ConclusionsThe carvedilol can obviously improve the inflammatory state and cardiac function of DCM patients, and there is not significant effect on blood lipid and blood glucose. |
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