| 108 例非霍奇金淋巴瘤预后因素分析 |
| |
| 引用本文： | 唐加明,陈安薇,彭文明,秦自科,梁国华,屈谦. 108 例非霍奇金淋巴瘤预后因素分析[J]. 中国肿瘤临床, 2010, 37(5): 274-276. DOI: 10.3969/j.issn.1000-8179.2010.05.010 |
| |
| 作者姓名： | 唐加明 陈安薇 彭文明 秦自科 梁国华 屈谦 |
| |
| 作者单位： | 作者单位:广州医学院第三附属医院肿瘤血液内科(广州市510150);①病理科;②中山大学肿瘤防治中心泌尿外科 |
| |
| 摘 要： | 目的:分析非霍奇金淋巴瘤（NHL ）的预后相关因素，探讨NHL 患者入院时外周血淋巴细胞绝对计数的预后价值。方法:回顾性分析2000年1 月至2008年1 月间108 例非霍奇金淋巴瘤患者的临床特征，结合随访资料，应用SPSS14.0 软件进行统计分析，采用Kaplan-Meier 法对生存概率进行评估，进一步采用Cox 回归模型对单因素分析中有统计学意义的参数进行多因素分析。结果:108 例非霍奇金淋巴瘤患者中，男女比例约为1. 5:1，中位年龄48岁。治疗前，61.1% 的患者为Ann ArborⅠ～Ⅱ期，ECOG 体力状态（performance status）评分0～1 的患者约占总数的93% ，乳酸脱氢酶升高见于19.2% 的患者，80.6% 的患者属于IPI低危组。入院时外周血淋巴细胞绝对计数减少（ALC ≤1 × 109/L ）见于35.2% 的患者，29.6% 的患者有贫血（Hb≤110g/L），26.9% 的患者伴有B 症状。ALC>1 × 109/L 患者70例，平均Hb为129.2 ± 17.5g/L，而ALC ≤1 × 109/L 患者38例，平均Hb为98.1 ± 20.6g/L（P<0.05）。 全组患者中位随访时间2 年，中位生存时间2.3 年，2 年和 5 年的总生存率分别为73.2%和39.6%。单因素生存分析显示，ALC ≤1 × 109/L、Hb≤110g/L、B 症状及国际预后指数（IPI）≥2 是NHL 的不良预后因素。多因素分析显示，ALC ≤1 × 109/L 、B 症状及IPI≥2是NHL 的独立不良预后因素。结论:外周血淋巴细胞绝对计数及B 症状是独立于国际预后指数之外的非霍奇金淋巴瘤预后指标。临床上，根据IPI 及简单的临床参数ALC 和B 症状判断NHL 预后，对实施个体化治疗可能具有更大实用价值。
|
| 关 键 词： | 淋巴细胞绝对计数 非霍奇金淋巴瘤 预后 |
| 收稿时间： | 2009-08-02 |
Analysis of Prognostic Factors of 108 Patients with Non-Hodgkin's Lymphoma |
| |
| TANG Jiaming,CHEN Anwei,PENG Wenming,QIN Zike,LIANG Guohua,QU Qian. Analysis of Prognostic Factors of 108 Patients with Non-Hodgkin's Lymphoma[J]. Chinese Journal of Clinical Oncology, 2010, 37(5): 274-276. DOI: 10.3969/j.issn.1000-8179.2010.05.010 |
| |
| Authors: | TANG Jiaming CHEN Anwei PENG Wenming QIN Zike LIANG Guohua QU Qian |
| |
| Affiliation: | 1Department of Hematology/Oncology, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150,China |
| |
| Abstract: | Objective: To analyze the prognostic factors of non-Hodgkin's lymphoma(NHL)and to investigate the prognostic value of peripheral blood absolute lymphocyte count(ALC)at admission for patients with NHL. Methods: Clinical features and follow-up data of 108 patients with pathologically confirmed NHL seen in our hospital between January 2000 and January 2008 were reviewed.SPSS14.0 package was used for statistical analysis.Kaplan-Meier was applied to assess the survival probability.All parameters statistically significant concluded by univariate analysis were then computed as co-variates for multivariate analysis with Cox regression model. Results: The ratio of males to females was approximately 1.5:1.The median age of patients was 48 years.Before treatment.the Ann Arbor clinical classification showed that 61.1% of the cases were of stage Ⅰ and Ⅱ.Approximately 93%of the patients had ECOG performance status(PS)score of 0-1 and 19.2%of the cases had elevated serum lactate dehydrogenase(LDH).According to intemational prognosis index score.80.6%of the patients were in a low risk group.At admission，35.2%of the cases had ALC≤1×10~9/L.Hemoglobin (Hb)≤110g/L and B symptoms were seen in 29.6%and 26.9%of the patients.The mean Hb was 129.2±17.5g/L in cases with ALC>1×10~9/L(n=70)and 98.1±20.6g/L in cases with ALC≤1×10~9/L(n=38),with a statistically significant difference between the two groups(P<0.05).With a median follow-up duration of 2 years，the median overall survival(OS)time was 2.3 years for all patients.The 2-year and 5-year OS rates were 73.2%and 39.6%，respectively.ALC≤1×10~9/L,Hb≤110g/L,B symptoms and intemational prognostic index(IPI)≥2 were statistically significant unfavorable prognostic factors for NHL revealed by univariate analysis.Multivariate analysis showed that ALC≤1×10~9/L,B symptoms and IPI ≥2 were statistically significant unfavorable prognostic factors for NHL. Conclusion: ALC and B symptoms may be prognostic factors independent of IPI for NHL.Evaluation of the prognosis with IPI,ALC，and B symptoms is of clinical value for individualized therapy of NHL patients. |
| |
| Keywords: | Absolute lymphocyte count Non-Hodgkin's lymphoma Prognosis |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《中国肿瘤临床》浏览原始摘要信息 |
|
点击此处可从《中国肿瘤临床》下载免费的PDF全文 |
|
