| HBeAg阴性慢性乙型肝炎患者血清25-羟基维生素D3的检测及临床意义 |
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| 引用本文： | 吴 刚,吴锦瑜.HBeAg阴性慢性乙型肝炎患者血清25-羟基维生素D3的检测及临床意义[J].医学信息,2018,0(19):96-98. |
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| 作者姓名： | 吴 刚 吴锦瑜 |
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| 作者单位： | 九江市第一人民医院肝病科，江西 九江 332000 |
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| 摘 要： | 目的 探究HBeAg阴性慢性乙型肝炎患者血清25-羟基维生素D3的水平变化及临床意义。方法 选取2015年3月~2018年5月81例HBeAg阴性且非肝硬化的慢性乙型肝炎患者作为观察组，依据血清谷丙转氨酶（ALT）水平分为观察组A 41例（ALT处于正常水平且HBV DNA水平＜2000 IU/ml，持续时间高于6个月）和观察组B 40例（ALT处于升高水平且HBV DNA水平≥2000 IU/ml，持续时间高于6个月）。同时选取同期健康体检人群40例作为对照组。分别检测三组血清25-羟基维生素D3的浓度。结果 观察组血清25-羟基维生素D3低于健康人群，统计学意义显著（P＜0.001），三组间比较，统计学意义显著（P＜0.001）。观察组患者血清25-羟基维生素D3与年龄、BMI、ALT、AST、Hb、WBC、PLT及AFP均无明显相关性（P＞0.05）。而与HBV DNA含量间存在显著负相关（r=-3.981，P＜0.05）。结论 HBeAg阴性慢性乙型肝炎患者血清25-羟基维生素D3存在异常，并与乙肝病毒复制相关，可能参与机体和乙肝病毒的免疫反应过程。
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| 关 键 词： | HBeAg阴性 慢性乙型肝炎 25-羟基维生素D3 HBV DNA |
Detection and Clinical Significance of Serum 25-hydroxyvitamin D3 in Patients with HBeAg-negative Chronic Hepatitis B |
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| WU Gang,WU Jin-yu.Detection and Clinical Significance of Serum 25-hydroxyvitamin D3 in Patients with HBeAg-negative Chronic Hepatitis B[J].Medical Information,2018,0(19):96-98. |
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| Authors: | WU Gang WU Jin-yu |
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| Affiliation: | Department of Liver Diseases,Jiujiang First People’s Hospital,Jiujiang 332000,Jiangxi,China |
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| Abstract: | Objective To investigate the changes and clinical significance of serum 25-hydroxyvitamin D3 levels in patients with HBeAg-negative chronic hepatitis B.Methods From March 2015 to May 2018,81 patients with HBeAg-negative and non-cirrhotic chronic hepatitis B were enrolled as observation group.According to serum alanine aminotransferase(ALT)levels,41 patients in observation group A(ALT was at normal level and HBV DNA level was <2000 IU/ml,duration was higher than 6 months)and 40 patients in group observation B(ALT was at elevated level and HBV DNA level was ≥2000 IU/ml for more than 6 months).At the same time,40 healthy people in the same period were selected as the control group.The concentrations of serum 25-hydroxyvitamin D3 were measured separately.Results The serum 25-hydroxyvitamin D3 in the observation group was lower than that in the healthy group,and the statistical significance was significant (P<0.001).The comparison between the three groups was statistically significant(P<0.001).There was no significant correlation between serum 25-hydroxyvitamin D3 and age,BMI,ALT,AST,Hb,WBC, PLT and AFP in the observation group(P>0.05).There was a significant negative correlation with HBV DNA content(r=-3.981,P<0.05).Conclusion The serum of 25-hydroxyvitamin D3 in patients with HBeAg-negative chronic hepatitis B is abnormal and related to hepatitis B virus replication, which may be involved in the immune response process between the body and hepatitis B virus. |
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| Keywords: | HBeAg negative Chronic hepatitis B 25-hydroxyvitamin D3 HBV DNA |
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