| 孕期高危型人乳头瘤病毒的流行病学特征及对妊娠结局的影响 |
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| 引用本文： | 孕期高危型人乳头瘤病毒的流行病学特征及对妊娠结局的影响.孕期高危型人乳头瘤病毒的流行病学特征及对妊娠结局的影响[J].首都医学院学报,2018,39(6):836-840. |
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| 作者姓名： | 孕期高危型人乳头瘤病毒的流行病学特征及对妊娠结局的影响 |
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| 作者单位： | 1. 首都医科大学附属北京朝阳医院妇产科, 北京 100020;2. 首都医科大学附属北京朝阳医院感染与微生物科, 北京 100020 |
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| 基金项目： | 国家自然科学基金青年科学基金项目（81702551）。 |
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| 摘 要： | 目的 探讨妊娠妇女孕期高危型人乳头瘤病毒（high risk-human papillomavirus， HR-HPV）的流行病学特征及其对妊娠结局的影响。方法 采用平行对照研究的方法，对首都医科大学附属北京朝阳医院2013年3月至2017年12月间建立孕产妇保健档案并接受HR-HPV 检查的3 967例孕妇，与同期、同年龄的非孕妇按照1∶3配对，分析孕期HR-HPV感染的流行病学特征，采用队列研究的方法分析孕期HR-HPV感染对妊娠结局的影响。结果 孕期HR-HPV的总感染率、多重混合感染、高病毒载量感染分布低于非孕期（P<0.05），型别分布与非孕期差异无统计学意义（P>0.05）。孕期HR-HPV感染率与年龄无明显相关性。HR-HPV感染的孕妇羊水过少发生率增高，急产发生率降低，差异有统计学意义（P<0.05）。结论 孕期HR-HPV感染不增加除羊水过少外其他不良妊娠结局的危险，孕期HR-HPV感染率及严重程度均低于非孕期女性。
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| 关 键 词： | 高危型人乳头瘤病毒 妊娠 流行病学 妊娠结局 |
| 收稿时间： | 2018-09-30 |
Epidemiological characteristics of high-risk human papillomavirus infection during pregnancy and the correlation between the high-risk human papillomavirus infection and the pregnancy outcomes |
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| Huang Wenyang,He Xin,Li Weihua,Zhang Xuefang,Li Zhan,Gu Li,Lu Junli,Wang Shuzhen.Epidemiological characteristics of high-risk human papillomavirus infection during pregnancy and the correlation between the high-risk human papillomavirus infection and the pregnancy outcomes[J].Journal of Capital University of Medical Sciences,2018,39(6):836-840. |
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| Authors: | Huang Wenyang He Xin Li Weihua Zhang Xuefang Li Zhan Gu Li Lu Junli Wang Shuzhen |
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| Affiliation: | 1. Department of Gynaecology and Obstetrics, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;2. Department of Infection and Microbiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China |
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| Abstract: | Objective To investigate the epidemiological characteristics of high-risk human papillomavirus(HR-HPV) in pregnant women during pregnancy and its effect on pregnancy outcomes. Methods From March 2013 to December 2017, a total of 3 967 pregnant women who established maternal health records and received HR-HPV examinations,1:3 paired non-pregnant women of the same age and the same period,were selected to investigate the epidemiological characteristics of HR-HPV infection during pregnancy by parallel controlled study, and to investigate the impact of HR-HPV infection on pregnancy outcome by Cohort study. Results The total infection rate, multiple mixed infection and high viral load of HR-HPV in pregnant women were lower than those in non-pregnant women (P<0.05). There was no significant correlation between the HR-HPV infection rate and age in pregnant women.For pregnant women with HR-HPV infection,the incidence of oligohydramnios increased while the incidence of acute labor decreased, and the differences were statistically significant (P<0.05). Conclusion HR-HPV infection during the pregnancy does not increase the risk of other adverse pregnancy outcomes except for oligohydramnios. The rate and severity of HR-HPV infection in the pregnancy women were lower than that in non-pregnancy women, which is inconsistent with most international data. It may be related to the significant decline in the sexual activities frequency of Chinese pregnant women. |
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| Keywords: | high-risk human papillomavirus pregnancy epidemiology pregnancy outcome |
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