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| 应用EDI-SDOCT观察全视网膜光凝对糖尿病视网膜病变黄斑区脉络膜厚度的影响 | |
| 引用本文： | 景作乾,柳力敏,陈蕾. 应用EDI-SDOCT观察全视网膜光凝对糖尿病视网膜病变黄斑区脉络膜厚度的影响[J]. 眼科新进展, 2015, 0(9): 839-843. DOI: 10.13389/j.cnki.rao.2015.0229 |
| 作者姓名： | 景作乾 柳力敏 陈蕾 |
| 作者单位： | 110001 辽宁省沈阳市，中国医科大学附属第一医院眼科 |
| 摘 要： | 目的 应用深层成像谱域光学相干断层扫描（ｅｎｈａｎｃｅｄｄｅｐｔｈｉｍａｇｉｎｇｓｐｅｃｔｒａｌ-ｄｏｍａｉｎｏｐｔｉｃａｌｃｏｈｅｒｅｎｃｅｔｏｍｏｇｒａｐｈｙ，ＥＤＩ-ＳＤＯＣＴ）观察全视网膜光凝（ｐａｎｒｅｔｉｎａｌｐｈｏｔｏｃｏａｇｕｌａｔｉｏｎ，ＰＲＰ）对非增生性糖尿病视网膜病变（ｎｏｎ-ｐｒｏｌｉｆｅｒａｔｉｖｅｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａ-ｔｈｙ，ＮＰＤＲ）患眼黄斑区脉络膜厚度的影响。方法 对３５例（５９眼）ＮＰＤＲ患者行ＰＲＰ术，以４２例（５９眼）正常眼作为对照组。应用ＥＤＩ-ＳＤＯＣＴ分别在ＰＲＰ术前和术后１周测量对照组和光凝组黄斑区各点位脉络膜厚度，比较术后１周较术前的变化，各点标记为:中心凹下脉络膜厚度（ｓｕｂｆｏｖｅａｌｃｈｏｒｏｉｄａｌｔｈｉｃｋｎｅｓｓ，ＳＦＣＴ），各扫描线上距离中心凹７５０μｍ、１５００μｍ处的鼻侧脉络膜厚度（ｎａｓａｌｃｈｏｒｏｉｄａｌｔｈｉｃｋｎｅｓｓ，ＮＣＴ）、颞侧脉络膜厚度（ｔｅｍｐｏｒａｌｃｈｏｒｏｉｄａｌｔｈｉｃｋｎｅｓｓ，ＴＣＴ）、上方脉络膜厚度（ｓｕｐｅｒｉｏｒｃｈｏｒｏｉｄａｌｔｈｉｃｋｎｅｓｓ，ＳＣＴ）、下方脉络膜厚度（ｉｎｆｅｒｉｏｒｃｈｏｒｏｉｄａｌｔｈｉｃｋｎｅｓｓ，ＩＣＴ）、平均黄斑区脉络膜厚度（ａｖｅｒａｇｅｍａｃｕｌａｒｃｈｏｒｏｉｄａｌｔｈｉｃｋｎｅｓｓ，ＡＭＣＴ）。结果 光凝组术前、术后１周的ＳＦＣＴ、ＮＣＴ７５０、ＴＣＴ７５０、ＳＣＴ７５０、ＩＣＴ７５０、ＮＣＴ１５００、ＴＣＴ１５００、ＳＣＴ１５００、ＩＣＴ１５００、ＡＭＣＴ均明显低于对照组（均为Ｐ＜０．０５）；术后１周ＳＦＣＴ和ＡＭＣＴ明显高于术前（均为Ｐ＜０．０５）；除ＴＣＴ７５０和ＴＣＴ１５００术后与术前无明显差异外（均为Ｐ＞０．０５），余各点位术后均明显高于术前（均为Ｐ＜０．０５）。其中１０眼术后各值低于术前，２眼可观察到术后脉络膜血管孔径较术前增加。结论 ＮＰＤＲ会导致黄斑区脉络膜变薄，ＰＲＰ术短期内能够明显增加黄斑区脉络膜厚度，同时一定程度上增加脉络膜的血管孔径。ＥＤＩ-ＳＤＯＣＴ是用于评价ＮＰＤＲ患者疗效和预后的有效无创检测手段。 |
| 关 键 词： | 糖尿病视网膜病变 全视网膜光凝 光学相干断层扫描 脉络膜厚度 |
Effects observation of panretinal photocoagulation on macular choroidal thickness of diabetic retinopathy by EDI-SDOCT |
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| JING Zuo-Qian,LIU Li-Min,CHEN Le. Effects observation of panretinal photocoagulation on macular choroidal thickness of diabetic retinopathy by EDI-SDOCT[J]. Recent Advances in Ophthalmology, 2015, 0(9): 839-843. DOI: 10.13389/j.cnki.rao.2015.0229 | |
| Authors: | JING Zuo-Qian LIU Li-Min CHEN Le |
| Affiliation: | Department of Ophthatmology ,the First Hospital of China Medical University , Shenyang 110001, Liaoning Province . China |
| Abstract: | Objective To observe the effects of panretinal photocoagulation ( PRP) on macular choroidal thickness ( CT) of non-proliferative diabetic retinopathy (NPDR) by enhanced depth imaging spectral-domain optical coherence tomography ( EDI-SDOCT) . Methods Fifity-rune NPDR eyes of 35 patients were underwent PRP. and 59 normal eyes of 42 normal ones were chosen as control. EDI-SDOCT was used to measure CT before PRP and I week after PRP at the point of 750 ym and 1500 ym on both of the horizontal and vertical scan lines in nasal,temporal, superior and inferior directions. The measured values were defrned as subfoveal CT ( SFCT) , nasal CT750 ( NCT750 ) , nasal CTisoo ( NCTisoc, ) , temporal CT750 ( TCT750 ) , temporal CTisoo ( TCTisoo ) , superior CT750 ( SCT750 ) , superior CTisoo ( SCTisoo ) , inferior CT750 ( ICT750 ) , inferior CT750 (ICTisoo ) , average macular choroidal thickness ( AMCT ) . Results SFCT, NCT750 , TCT750 , SCT750 , ICT750 , NCTisoo , TCTisoo , SCTisoo , ICTisoo , AMCT at pre-operation and I week after PRP in the PRP group were sigruficant lower than those in the control group ( all P < 0. 05 ) . SFCT and AMCT at postoperative I week in PRP group were higher than those at pre-operation ( all P < 0. 05 ) . TCT750 and TCTisoo showed no sigruficant difference between pre-operation and post-operation ( all P > 0. 05 ) . while the postoperative SFCT . NCT750 , SCT750 , ICT750 , NCTisoo , SCTisoo , ICTisoo and AMCT in PRP group were significant higher than pre-operation ( all P < 0. 05 ) . Above values lower than pre-operation were in 10 eyes. A increase of vessels diameter were observed in 2 eyes. Conclrision NPDR induce a decrease in macular CT.while PRP induce a significant increase in a short term and expand the vessel diameter in a certain extent. EDI-SDOCT can be used as an effective and non-invasive method for evaluating the efficacy and prognosis of NPDR. |
| Keywords: | diabetic retinopathy panretinal photocoagulation optical coherence tomography choroidal thickness |
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