Specificity of human antibodies reactive with pneumococcal C polysaccharide |
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| Authors: | Frasch C E Concepcion N F |
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| Affiliation: | Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Bethesda, Maryland, USA. frasch@cber.fda.gov |
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| Abstract: | ![]()
Antibodies reactive with C polysaccharide (PS) were found in healthy adults, pneumococcal patients, and vaccinees. These antibodies were not directed to the phosphocholine determinant of the C PS, as they appear to be in mice, since the human antibodies were inhibitable only with C PS. We found another population of phosphocholine-specific antibodies inhibitable only by phosphocholine and related compounds. |
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