| 依巴斯汀治疗慢性荨麻疹临床疗效的Meta分析 |
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| 引用本文： | 徐翔,杨燕,梁东辉,马红利,牛香群. 依巴斯汀治疗慢性荨麻疹临床疗效的Meta分析[J]. 药物流行病学杂志, 2011, 0(11): 568-574 |
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| 作者姓名： | 徐翔 杨燕 梁东辉 马红利 牛香群 |
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| 作者单位： | 长江航运总医院(武汉 430010);药物流行病学杂志社。;长江航运总医院(武汉 430010);长江航运总医院(武汉 430010);长江航运总医院(武汉 430010) |
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| 摘 要： | 目的:评价依巴斯汀治疗慢性荨麻疹临床疗效及不良反应。方法:计算机检索Cochrane图书馆、PubMed、EMbase、中国知网和万方数据库。检索时间均为建库至2011年2月。收集以依巴斯汀与其他药物对照治疗慢性荨麻疹的随机对照临床试验(RCT)。评价纳入文献的研究质量,提取有效数据,采用RevMan 5.0软件进行Meta分析。结果:共纳入12个研究,包括1567例慢性荨麻疹患者。Meta分析结果显示,依巴斯汀治疗慢性荨麻疹临床疗效较其他抗组胺药高;依巴斯汀联合用药或其他抗组胺药联合用药治疗慢性荨麻疹临床疗效比单一应用依巴斯汀的疗效高,但复发率比较差异无统计学意义;依巴斯汀治疗慢性荨麻疹的不良反应与依巴斯汀联合用药或其他抗组胺药联合用药比较,差异无统计学意义。结论:依巴斯汀能有效治疗慢性荨麻疹,不良反应少。由于慢性荨麻疹病因复杂,且本次研究仍有局限性,还需要更多大样本、设计严格的随机临床对照试验加以证实。
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| 关 键 词： | 依巴斯汀 慢性荨麻疹 Meta分析 |
| 收稿时间： | 2011-06-30 |
| 修稿时间： | 2011-09-13 |
Effect and Safety of Ebastine on Chronic Urticaria:A Meta-analysis of Randomized Controlled Trials |
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| Xu Xiang,Yang Yan,Liang Donghui,Ma Hongli and Niu Xiangqun. Effect and Safety of Ebastine on Chronic Urticaria:A Meta-analysis of Randomized Controlled Trials[J]. Chinese Journal of Pharmacoepidemiology, 2011, 0(11): 568-574 |
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| Authors: | Xu Xiang Yang Yan Liang Donghui Ma Hongli Niu Xiangqun |
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| Affiliation: | General Hospital of the Yangtze River Shipping Co., Wuhan 430010, China;Agency of the Chinese Journal of Pharmacoepidemiology;General Hospital of the Yangtze River Shipping Co., Wuhan 430010, China;General Hospital of the Yangtze River Shipping Co., Wuhan 430010, China;General Hospital of the Yangtze River Shipping Co., Wuhan 430010, China |
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| Abstract: | Objective:To evaluate the efficacy and safety of ebastine on patients with chronic urticaria(CU ). Method:The electronic databases(the Cochrane Library,PubMed,EMbase,CNKI and WANFANG DATA ) were searched in order to retrieve randomized controlled trials(RCT) about comparing ebastine with other drug therapy for CU. The related references were traced to obtain the information.The Jadad' s scale and Cochrane collaboration ' s RevMan 5.0 soft-ware were used to assess the trial methodological quality and data an... |
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| Keywords: | Ebastine Chronic urticaria Meta-analysis |
| 本文献已被 CNKI 维普 等数据库收录！ |
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