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Hand‐foot‐skin reaction related to use of the multikinase inhibitor sorafenib and hard orthotics |
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| Authors: | Ayan Kusari MA Jenna Borok MAS Allison M Han AB Alix Jessika Valderrama MD Sheila Fallon Friedlander MD |
| Affiliation: | 1. Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, CA, USA;2. Departments of Dermatology and Pediatrics, School of Medicine, University of California, San Diego, CA, USA;3. David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;4. Department of Dermatology, Centro de Especialistas, Hospital Fundación Cardioinfantil, Bogotá, Colombia |
| Abstract: | Hand‐foot‐skin reaction is a distinct clinical condition arising in association with the use of multikinase inhibitors, including sorafenib. Because multikinase inhibitors are increasingly being used in children with cancer, recognition of this previously unfamiliar condition is of importance to pediatric dermatologists. We describe the diagnosis and successful treatment of a case of hand‐foot‐skin reaction in a child taking sorafenib for an unresectable desmoid tumor. |
| Keywords: | hand‐foot skin reaction hyperkeratotic lesions keratolytics multikinase inhibitors sorafenib topical corticosteroids |
