Vitreous penetration of levofloxacin in the uninflamed phakic human eye |
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| Authors: | Herbert E N Pearce I A McGalliard J Wong D Groenewald C |
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| Affiliation: | St Paul's Eye Unit, 8Z Link, Royal Liverpool University Hospital, Liverpool L7 8XP, UK. enherbert@doctors.org.uk |
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| Abstract: | ![]()
AIMS: To assess the vitreous penetration of oral levofloxacin (a new fluoroquinolone antibiotic with improved Gram positive activity) in uninflamed phakic eyes. METHODS: 15 patients for macula hole surgery were recruited to the study. 10 received a single 500 mg dose of levofloxacin by mouth preoperatively. Five acted as controls. Serum and undiluted vitreous samples were obtained at surgery and analysed by HPLC. RESULTS: Levofloxacin was detectable 2.5 hours after administration in the vitreous. A peak concentration of 1.6 microg/ml (or mg/l) was measured between 2.5 and 4 hours post-dose. CONCLUSION: Oral levofloxacin reaches the vitreous rapidly in the uninflamed phakic eye. Levels did not reach MIC(90) for the commonest infecting organisms. Nevertheless, levofloxacin would be expected to be active against a higher proportion of infecting organisms than either ciprofloxacin or ofloxacin. |
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