| P2RY6在非小细胞肺癌中的表达和临床意义分析 |
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| 引用本文： | 周永生,熊延路,冯杨波,乔天运,赵晋波,雷杰,姜涛,韩勇.P2RY6在非小细胞肺癌中的表达和临床意义分析[J].中国肿瘤临床,2020,47(19):977-984. |
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| 作者姓名： | 周永生 熊延路 冯杨波 乔天运 赵晋波 雷杰 姜涛 韩勇 |
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| 作者单位： | ①.空军军医大学唐都医院胸腔外科(西安市 710038) |
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| 基金项目： | 国家自然科学基金项目81772462 |
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| 摘 要： | 目的 探讨P2RY6在非小细胞肺癌（non-small cell lung cancer，NSCLC）患者中的表达及临床意义。 方法 在基因表达集（Gene Expression Omnibus，GEO）和癌症基因组图谱计划（The Cancer Genome Atlas Program，TCGA）数据库中获取多个NSCLC、肺腺癌和肺鳞癌的基因表达以及临床信息数据集。使用非参数检验分析癌组织与邻近正常组织的P2RY6表达水平差异，并且通过免疫组织化学研究肺鳞癌及肺腺癌组织和正常组织的P2RY6蛋白表达情况。使用χ2检验分析P2RY6表达与肺腺癌、肺鳞癌患者临床特征之间的相关性。使用Kaplan-Meier方法和Log-rank检验评估肺腺癌和肺鳞癌P2RY6表达水平与总生存期和无进展生存期之间的关系。使用Cox比例风险回归模型进一步评估P2RY6表达量对肺鳞癌患者总生存期和无进展生存期的预测效能。 结果 P2RY6在NSCLC、肺腺癌和肺鳞癌中均高表达。在肺腺癌患者中，P2RY6表达与生存无关，而与性别有关。在P2RY6高表达的肺鳞癌患者中，总生存期和无进展生存期较短，P2RY6高表达是独立危险因素。 结论 P2RY6与肺鳞癌患者的生存相关，P2RY6高表达预示着肺鳞癌患者总生存期与无进展生存期较短，是预后不良的独立危险因素。
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| 关 键 词： | 非小细胞肺癌 P2Y6受体 预后 |
| 收稿时间： | 2020-06-17 |
Expression and clinical significance of P2RY6 in non-small cell lung cancer |
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| Affiliation: | ①.Department of Thoracic Surgery, Tangdu Hospital of Air Force Medical University, Xi'an 710038, China②.Department of Thoracic Surgery, Air Force Medical Center, PLA, Beijing 100142, China |
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| Abstract: | Objective To investigate the expression level of pyrimidinergic receptor P2Y6 (P2RY6) and its clinical implications in patients with non-small cell lung cancer (NSCLC). Methods We obtained the gene expression profiles and clinical datasets of patients with NSCLC, lung squamous cell carcinoma, and lung adenocarcinoma from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data bases. A nonparametric test was used to analyze the differences in P2RY6 expression levels between cancer tissues and adjacent normal tissues. Immunohistochemistry was performed to investigate the expression of P2RY6 in lung squamous cell carcinoma or lung adenocarcinoma and adjacent normal tissues. A Chi-square test was applied to validate any correlations between P2RY6 expression levels and the clinical features of patients with lung squamous cell carcinoma and lung adenocarcinoma. Furthermore, the relationship between P2RY6 expression and overall or progression-free survival (PFS) was evaluated using the KaplanMeier method and Log-rank tests. Finally, a Cox proportional hazard regression model was applied to appraise the predictive ability of P2RY6 expression levels for the survival of patients with lung squamous cell carcinoma. Results P2RY6 was abundantly expressed in NSCLC, lung adenocarcinoma, and lung squamous cell carcinoma tissues. Among patients with lung adenocarcinoma, a high expression level of P2RY6 was associated with sex but not survival. Among patients with lung squamous cell carcinoma showing high expression levels of P2RY6, both overall survival (OS) and PFS were short. This suggests that high expression levels of P2RY6 may be a new independent risk factor for survival in patients with lung squamous cell carcinoma. Conclusions P2RY6 is associated with the survival of patients with lung squamous cell carcinoma. A high expression level of P2RY6 indicates shorter OS and PFS and may be a novel independent risk factor for survival in patients with lung squamous cell carcinoma. |
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