Muscarinic receptors participation in angiogenic response induced by macrophages from mammary adenocarcinoma-bearing mice |
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| Authors: | Eulalia?de la Torre,Lilia?Davel,María?A?Jasnis,Tomomi?Gotoh,Eugenia?Sacerdote?de Lustig,María?E?Sales mailto:mesales@vias.com.ar" title=" mesales@vias.com.ar" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | Departamento de Inmunobiología, Instituto de Oncología A.H. Roffo, Universidad de Buenos Aires, Buenos Aires, Argentina. eulaliadelatorre@hotmail.com.ar |
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| Abstract: | ![]()
Introduction The role of macrophages in tumor progression has generated contradictory evidence. We had previously demonstrated the ability of peritoneal macrophages from LMM3 murine mammary adenocarcinoma-bearing mice (TMps) to increase the angiogenicity of LMM3 tumor cells, mainly through polyamine synthesis. Here we investigate the ability of the parasympathetic nervous system to modulate angiogenesis induced by TMps through the activation of the muscarinic acetylcholine receptor (mAchR). |
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