| 他汀类药物的使用和颅内动脉瘤破裂相关性分析 |
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| 引用本文： | 汪林涛,赵,平,任永生,潘泰峰,王,恒,杨建权,赵斌杰,唐振刚.他汀类药物的使用和颅内动脉瘤破裂相关性分析[J].中国临床神经外科杂志,2015,0(10):614-616. |
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| 作者姓名： | 汪林涛 赵 平 任永生 潘泰峰 王 恒 杨建权 赵斌杰 唐振刚 |
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| 作者单位： | 442000 湖北十堰，湖北医药学院附属人民医院神经外科（汪林涛、赵 平、潘泰峰、王 恒、杨建权、赵斌杰、唐振刚）；442000 湖北十堰，湖北医药学院生理教研室（任永生）
通讯作者:赵 平，E-mail:94274165@qq.com |
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| 摘 要： | 目的 探讨他汀类药物对颅内动脉瘤破裂的影响。方法 2010年3月至2014年3月收治颅内囊状动脉瘤67例，其中破裂者32例，未破裂者35例。采用多变量Logistic回归评估他汀类药物的使用和颅内动脉瘤破裂的关系。结果 破裂组术前使用他汀类药物4例（12.5%，4/32），未破裂组16例（45.7%，16/35）。破裂组服用他汀类药物的百分比显著低于未破裂组（P<0.01）。纠正潜在的混杂干扰后（or值: 0.30，95%可信空间:0.12~="" 0.64）显示，颅内动脉瘤破裂与他汀类药物的使用呈显著负相关，也与高血清总胆固醇浓度有关。结论 本结果提示他汀类药物对颅内动脉瘤破裂有一定的预防效果。
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| 关 键 词： | 他汀类药物 颅内动脉瘤 蛛网模下腔出血 |
Analysis of relativity of statin with rupture of intracranial aneurysm |
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| WANG Lin-tao,ZHAO Ping,REN Yong-sheng,PAN Tai-feng,WANG Heng,YANG Jian-quan,ZHAO Bjin-jie,TANG Zhen-gang..Analysis of relativity of statin with rupture of intracranial aneurysm[J].Chinese Journal of Clinical Neurosurgery,2015,0(10):614-616. |
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| Authors: | WANG Lin-tao ZHAO Ping REN Yong-sheng PAN Tai-feng WANG Heng YANG Jian-quan ZHAO Bjin-jie TANG Zhen-gang |
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| Affiliation: | 1. Department of Neurosurgery, Affiliated People’s Hospital, Hubei College of Medicine and Pharmacy, Shiyan 442000, China; 2. Department of Physiology, Hubei College of Medicine and Pharmacy, Shiyan 442000, China |
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| Abstract: | Objective To explore the effect of statin on the rupture of intracranial aneurysms. Methods Of 67 patients with intracranial saccate aneurysms treated from March, 2010 to March, 2014, 32 had ruptured intracranial aneurysms and 35 unruptured intracranial aneurysms. The relationship between statin and the rupture risk of intracranial aneurysm was analyzed by multivariable logistic regression. Results The percentage (45.7%, 16/35) of the patients who received statin treatment was significantly higher in the unruptured group than that (12.5%, 4/32) in the ruptured group before the surgical treatment (P |
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| Keywords: | Statin Intracranial aneurysm subarachnoid hemorrhage Rupture Relationship |
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