First isolation of metallo-beta-lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil |
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| Authors: | Lincopan Nilton McCulloch John Anthony Reinert Cristina Cassettari Valéria C Gales Ana C Mamizuka Elsa M |
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| Affiliation: | Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas,1. Comissão de Controle de Infecção Hospitalar, Hospital Universitário, Universidade de São Paulo,2. Laboratório Especial de Microbiologia Clínica, Disciplina de Doenças Infecciosas e Parasitárias, Universidade Federal de São Paulo, São Paulo, Brazil3. |
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| Abstract: | ![]()
A multiresistant Klebsiella pneumoniae isolate was taken from the blood of a 75-year-old patient with nosocomial pneumonia who developed septic shock and failed therapy with imipenem. The isolate presented an MIC of imipenem of 128 microg/ml, and the production of a metallo-beta-lactamase was confirmed by phenotypic and genotypic techniques. We here report, for the first time, the detection of a metalloenzyme (IMP-1)-producing K. pneumoniae clinical strain in Latin America. The gene responsible for this phenotype was found to be bla(IMP-1), carried in a class 1 integron. |
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