Efficacy and safety of creatine supplementation in juvenile dermatomyositis: A randomized,double‐blind,placebo‐controlled crossover trial |
| |
| Authors: | Marina Yazigi Solis PhD Ana Paula Hayashi MS Guilherme Giannini Artioli PhD Hamilton Roschel PhD Marcelo Tatit Sapienza PhD Maria Concepción Otaduy PhD Ana Lucia De Sã Pinto PhD Clovis Artur Silva PhD Adriana Maluf Elias Sallum PhD Rosa Maria R. Pereira PhD Bruno Gualano PhD |
| |
| Affiliation: | 1. School of Medicine, University of S?o Paulo, Sao Paulo, Brazil;2. School of Physical Education and Sport, University of S?o Paulo, Sao Paulo, Brazil |
| |
| Abstract: | Introduction: It has been suggested that creatine supplementation is safe and effective for treating idiopathic inflammatory myopathies, but no pediatric study has been conducted to date. The objective of this study was to examine the efficacy and safety of creatine supplementation in juvenile dermatomyositis (JDM) patients. Methods: In this study, JDM patients received placebo or creatine supplementation (0.1 g/kg/day) in a randomized, crossover, double‐blind design. Subjects were assessed at baseline and after 12 weeks. The primary outcome was muscle function. Secondary outcomes included body composition, aerobic conditioning, health‐related quality of life, and muscle phosphocreatine (PCr) content. Safety was assessed by laboratory parameters and kidney function measurements. Results: Creatine supplementation did not affect muscle function, intramuscular PCr content, or any other secondary outcome. Kidney function was not affected, and no side effects were reported. Conclusions: Twelve weeks of creatine supplementation in JDM patients were well‐tolerated and free of adverse effects, but treatment did not affect muscle function, intramuscular PCr, or any other parameter. Muscle Nerve 53 : 58–66, 2016 |
| |
| Keywords: | creatine supplementation juvenile dermatomyositis muscle metabolism phosphocreatine physical function |
|
|
