Mechanisms of human cytomegalovirus infection with a focus on epidermal growth factor receptor interactions |
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| Authors: | Aline Semblano Carreira Falcão Pedro Fernando da Costa Vasconcelos Dorotéa de Fátima Lobato da Silva João de Jesus Viana Pinheiro Luiz Fábio Magno Falcão Juarez Antonio Simões Quaresma |
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| Affiliation: | 1. Division of Infectious Diseases, Evandro Chagas Institute, Ananindeua, Pará, Brazil;2. Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ananindeua, Pará, Brazil;3. Environment Section, Laboratory of Virology and Molecular Biology, Evandro Chagas Institute, Ananindeua, Pará, Brazil;4. Department of Oral and Maxillofacial Pathology, School of Dentistry, Federal University of Pará, Belém, Pará, Brazil;5. Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S?o Paulo, S?o Paulo, Brazil;6. Center for Biological Sciences and Health, Pará State University, Belém, Pará, Brazil;7. Division of Infectious Diseases, Tropical Medicine Center, Federal University of Pará, Belém, Pará, Brazil |
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| Abstract: | Human cytomegalovirus (HCMV) is a widespread opportunistic herpesvirus that causes severe diseases in immunocompromised individuals. It has a high prevalence worldwide that is linked with socioeconomic factors. Similar to other herpesviruses, HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. HCMV infects a broad range of cell types. This broad tropism suggests that it may use multiple receptors for host cell entry. The identification of receptors used by HCMV is essential for understanding viral pathogenesis, because these receptors mediate the early events necessary for infection. Many cell surface components have been identified as virus receptors, such as epidermal growth factor receptor (EGFR), which is characterized by tyrosine kinase activity and plays a crucial role in the control of key cellular transduction pathways. EGFR is essential for HCMV binding, signaling, and host cell entry. This review focuses on HCMV infection via EGFR on different cell types and its implications for the cellular environment, viral persistence, and infection. |
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| Keywords: | cell surface receptor cytomegalovirus DNA virus infections epidermal growth factor receptor signal transduction |
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